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Intern
    THE HÖBARTNER GROUP: ORGANIC AND BIOMOLECULAR CHEMISTRY

    2018

    M.V. Sednev, V. Mykhailiuk, P. Choudhury, J. Halang, K.E. Sloan, M.T. Bohnsack,  C. Höbartner,
    N6-methyladenosine-sensitive RNA-cleaving deoxyribozymes.
    Angew. Chem. Int. Ed.  2018, 57, 15117-15121.(VIP) first published October 1, 2018. SI

    B. Moro, U. Chorostecki, S. Arikit, I.P. Suarez, C. Höbartner, R.M. Rasia, B.C. Meyers, J.F. Palatnik, Efficiency and precision of microRNA biogenesis modes in plants.
    Nucleic Acids Res.  2018, 46, 10709–10723. SI

    J. Dietzsch, D. Feineis, C. Höbartner, Chemoselective labeling and site-specific mapping of 5-formylcytosine as a cellular nucleic acid modification.
    FEBS Lett.  2018, 592, 2032-2047.

    J. Kretschmer, H. Rao, P. Hackert, K.E. Sloan, C. Höbartner, M.T. Bohnsack,
    The m6 A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5’-3’ exoribonuclease XRN1.
    RNA  201824, 1339-1350.

    2017

    A.S. Warda, J. Kretschmer, P. Hackert, C. Lenz, H. Urlaub, C. Höbartner, K.E. Sloan, M.T. Bohnsack,Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs.
    EMBO Reports  2017, 18, 2004-2014. SI

    T. J. Carrocci, L. Lohe, M. J. Ashton, C. Höbartner and A. Hoskins,
    Debranchase-resistant labeling of RNA using the 10DM24 deoxyribozyme and fluorescent modified nucleotides.
    Chem. Commun.  2017, 53, 11992-11995. SI

    M.A. Gomes de Castro, C. Höbartner, F. Opazo,
    Staining of Membrane Receptors with Fluorescently-labeled DNA Aptamers for Super-resolution Imaging.
    Bio-protocol 7(17): e2541.

    P. Bao, C. Höbartner, K. Hartmuth, R. Lührmann,
    Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing.
    RNA  2017, 1770-1779.

    S. Haag, K.E. Sloan, C. Höbartner, M.T. Bohnsack, In Vitro Assays for RNA Methyltransferase Activity.
    Methods Mol. Biol.  2017, 1562 : 259-268.

    M.A. Gomes de Castro, C. Höbartner, F. Opazo, Aptamers provide superior stainings of cellular receptors studied under super-resolution microscopy.
    PLoS One  2017, 12, e0173050.

    K.E. Sloan, C. Höbartner, M.T. Bohnsack, How RNA modification allows nonconventional decoding in mitochondria.
    Cell Cycle  2017, 16, 145-146. (invited Feature)

    2016

    S. Haag, K.E. Sloan, N. Ranjan, A.S. Warda, J. Kretschmer, C. Blessing, B. Hübner, J. Seikowski, S. Dennerlein, P. Rehling, M.V. Rodnina, C. Höbartner, M.T. Bohnsack,
    NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation.
    EMBO Journal  2016, 35, 2104-2119. SI

               comments by others:
               F. Boos, M. Wollin, J.M. Herrmann,
               Methionine on the rise: how mitochondria changed their codon usage.
               News & Views EMBO J.  2016 Aug 30.

    A. Ponce-Salvatierra, K. Wawrzyniak-Turek, U. Steuerwald, C. Höbartner, V. Pena, Crystal structure of a DNA catalyst.
    Nature  2016, 529, 231-234.

               comments by others:
               K. Woolcock, Structure of a DNA enzyme.Nat. Struct. Mol. Biol.2016, 23, 97.
               T.L. Sheppard, Catalytic DNA: Ligating with lambda.Nat. Chem. Biol.2016, 12, 125.
               M. Kostic, Select: Structure of a DNAzyme.Cell Chem Biol.2016 Feb 18;23(2):200.
               J. Wirmer-Bartoschek, H. Schwalbe, Understanding How DNA Enzymes Work.
               Angew. Chem. Int. Ed.2016, 55, 5376.
               Press release: MPIbpc, Univ. Göttingen
                 F1000Prime Recommendations by S.K. Silverman; D. Wetmore; B. Seelig; I. Hirao;
               total score: 11. 
               Scientists Report First Crystal Structure Of A DNAzyme C&E News

    M. Theuser, C. Höbartner, M.C. Wahl, K.F. Santos, Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase.
    Proc. Natl. Acad. Sci. USA. 2016, 113, 7798-7803. SI

    B. Samanta, J. Seikowski, C. Höbartner, Fluorogenic labeling of 5-formylpyrimidines in DNA and RNA.
    Angew. Chem. Int. Ed.  2016, 55, 1912-1916. SI

    F. Javadi-Zarnaghi, C. Höbartner, Functional hallmarks of a catalytic DNA that makes lariat RNA.
    Chem. Eur. J.  2016, 22, 3720-3726. SI

    K. Halbmair, J. Seikowski, I. Tkach, C. Höbartner, D. Sezer, M. Bennati, High-resolution measurement of long-range distances in RNA: pulse EPR spectroscopy with TEMPO-labeled nucleotides.Chem. Sci.  2016, 7, 3172-3180. SI

    S. Kwiatkowski, V.M. Sviripa, Z. Zhang, A.E. Wendlandt, C. Höbartner, D.S. Watt*, S. Stamm*, Synthesis of a norcantharidin-tethered guanosine: Protein phosphatase-1 inhibitors that change alternative splicing.
    Bioorg. Med. Chem. Lett.  2016, 26, 965-968. SI (* co-corresponding author)

    2015

    M. Kosutic, S. Neuner, A. Ren, S. Flür, C. Wunderlich, E. Mairhofer, N. Vusurovic, J. Seikowski, K. Breuker, C. Höbartner, D.J. Patel, C. Kreutz, R. Micura, A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class.
    Angew. Chem. Int. Ed.  2015, 54, 15128-15133. SI

    S. Haag, A.S. Warda, J. Kretschmer, M.A. Günnigmann, C. Höbartner, M.T. Bohnsack, NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs.
    RNA  2015, 21, 1532-1543. SI

    E. Turriani, C. Höbartner, T.M. Jovin, Mg2+-dependent conformational changes and product release during DNA-catalyzed RNA ligation monitored by Bimane fluorescence.Nucleic Acids Res.  2015, 43, 40-50. SI

    Z. Warkocki, C. Schneider, S. Mozaffari-Jovin, J. Schmitzová, C. Höbartner, P. Fabrizio, R. Lührmann, The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome.Genes Dev.  2015, 29, 94-107. SI

    2014

    C.C. Lin, J. Seikowski, A. Pérez-Lara, R. Jahn, C. Höbartner, P.J. Walla, Control of membrane gaps by synaptotagmin-Ca2+ measured with a novel membrane distance ruler.
    Nat. Commun.  2014 Dec 15; 5, 5859. SI

    L. Büttner, F. Javadi-Zarnaghi, C. Höbartner, Site-specific labeling of RNA at internal ribose hydroxyl groups: terbium-assisted deoxyribozymes at work.
    J. Am. Chem. Soc.  2014, 136, 8131-8137. SI

    K. Wawrzyniak-Turek, C. Höbartner, Enzymatic combinatorial nucleoside deletion scanning mutagenesis of functional RNA.
    Chem. Commun.  2014, 50, 10937-10940. SI

    K. Wawrzyniak-Turek, C. Höbartner, Deoxyribozyme-mediated ligation for incorporating EPR spin labels and reporter groups into RNA.
    Methods Enzymol.  2014, 549, 85-104.

    B. Schmidtgall, F. Wachowius, C. Höbartner, C. Ducho, Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure.
    Chem. Commun.  2014, 50, 13742-13745. SI

    I. Tkach, K. Halbmair, C. Höbartner, M. Bennati, High-frequency 263 GHz PELDOR. Appl.
    Magn. Res.
      2014, 45, 969-979.

    2013

    F. Javadi-Zarnaghi, C. Höbartner, Lanthanide cofactors accelerate DNA-catalyzed synthesis of branched RNA.
    J. Am. Chem. Soc.  2013, 135, 12839-12848. SI

    L. Büttner, J. Seikowski, K. Wawrzyniak, A. Ochmann, C. Höbartner, Synthesis of spin-labeled riboswitch RNAs using convertible nucleosides and DNA-catalyzed RNA ligation.
    Bioorg. Med. Chem.  2013, 21, 6171-6180. SI

    B. Samanta, C. Höbartner, Combinatorial Nucleoside-Deletion-Scanning Mutagenesis of Functional DNA.
    Angew. Chem. Int. Ed.  2013, 52, 2995-2999. Angew. Chem.2013, 125, 3069-3073. SI

    I. Tkach, S. Pornsuwan, C. Höbartner, F. Wachowius, S.T. Sigurdsson, T. Baranova, U. Diederichsen, G. Sicoli, M. Bennati, Orientation selection in distance measurements between nitroxide spin labels at 94 GHz EPR with variable dual frequency irradiation.Phys. Chem. Chem. Phys.  2013, 15, 3433-3437. SI

    2012

    C. Höbartner*, G. Sicoli, F. Wachowius, D.B. Gophane, S.T. Sigurdsson*, Synthesis and Characterization of RNA Containing a Rigid and Nonperturbing Cytidine-Derived Spin Label.
    J. Org. Chem.  2012, 77, 7749-7754. SI (* co-corresponding authors)

    G.N. Nawale, K.R. Gore, C. Höbartner*, P.I. Pradeepkumar*, Incorporation of 4'-C-aminomethyl-2'-O-methylthymidine into DNA by thermophilic DNA polymerases.
    Chem. Commun.  2012, 48, 9619-9621. (* co-corresponding authors)

    K.R. Gore, G.N. Nawale, S. Harikrishna, V. G. Chittoor, S.K. Pandey, C. Höbartner, S. Patankar, P.I. Pradeepkumar, Synthesis, Gene Silencing, and Molecular Modeling Studies of 4'-C-Amino-methyl-2'-O-methyl Modified Small Interfering RNAs.J. Org. Chem.  2012, 77, 3233-3245. SI

    C. Höbartner, Enzymatic labeling of 5-hydroxymethylcytosine in DNA.
    Angew. Chem. Int. Ed.  2011, 50, 4268-4270. Angew. Chem.2011, 123, 4357-4359. (Highlight)

    I. Tkach, G. Sicoli, C. Höbartner and M. Bennati, A dual-mode microwave resonator for double electron-electron spin resonance spectroscopy at W-band microwave frequencies.J. Mag. Res.  2011, 209, 341-346.

    2010

    F. Wachowius, F. Javadi-Zarnaghi, C. Höbartner, Combinatorial Mutation Interference Analysis reveals functional nucleotides required for DNA catalysis.
    Angew. Chem. Int. Ed.  2010, 49, 8504-8508. Angew. Chem.2010, 122, 8682-8687. SI

               comments by others
               comment in Faculty of 1000 Biology: Müller S.: 2010.

    G. Sicoli, F. Wachowius, M. Bennati, C. Höbartner*, Secondary Structure Probing of Spin-labeled RNA by Pulsed EPR Spectroscopy.
    Angew. Chem. Int. Ed.  2010, 49, 6443-6447. Angew. Chem.  2010, 122, 6588-6592.
    SI (* co-corresponding author)

    F. Wachowius, C. Höbartner, Chemical RNA modifications for studies of RNA structure and dynamics.
    ChemBioChem  2010, 11, 469-480.

    2009

    D.A. Heller, H. Jin, B.M. Martinez, D. Patel, B.M. Miller, T.-K. Yeung, P.V. Jena, C. Höbartner, T. Ha, S.K. Silverman, M.S. Strano, Multimodal optical sensing and analyte specificity using single-walled carbon nanotubes.
    Nat. Nanotechnol.  2009, 4, 114-120. SI

               comments by others
                 News & views: T.D. Krauss, Nat. Nanotechnol.2009, 4, 85-86.

    R. Rieder, C. Höbartner, R. Micura, Enzymatic ligation strategies for the preparation of purine riboswitches with site-specific chemical modifications.
    in Riboswitches (Ed. A. Serganov), Methods Mol. Biol.  2009, 540, 15-24.

    2008

    P. I. Pradeepkumar, C. Höbartner, D.A. Baum S. K. Silverman, DNA-catalyzed formation of nucleopeptide linkages.
    Angew. Chem. Int. Ed.  2008, 47, 1753-1757. Angew. Chem.  2008, 120, 1777-1781. SI

    2007

    C. Höbartner, S. K. Silverman, Recent Advances in DNA Catalysis.
    Biopolymers  2007, 87, 279-292.

    C. Höbartner, S. K. Silverman, Engineering a Selective Small-Molecule Substrate Binding Site into a Deoxyribozyme.
    Angew. Chem. Int. Ed.  2007, 46, 7420-7424. Angew. Chem.  2007, 119, 7564-7568. SI

    C. Höbartner, P. I. Pradeepkumar, S. K. Silverman, Site-Selective Depurination by a Periodate-Dependent Deoxyribozyme.
    Chem. Commun.  2007, 2255-2257.

    2006

    R. Micura, C. Höbartner, R. Rieder, C. Kreutz, B. Puffer, K. Lang, H. Moroder, Preparation of 2'-Deoxy-2'-Methylseleno-Modified RNA.
    Current Protocols in Nucleic Acid Chemistry  2006, 1.15.1-1.15.34.

    2005

    C. Höbartner, S. K. Silverman, Modulation of RNA tertiary folding by incorporation of caged nucleotides.
    Angew. Chem.  2005, 117, 7471-7475; Angew. Chem. Int. Ed.  2005, 44, 7305-7309. SI

    C. Höbartner, R. Rieder, C. Kreutz, B. Puffer, K. Lang, A. Polonskaia, A. Serganov, R. Micura, Syntheses of RNAs with up to 100 nucleotides containing site-specific 2'-Se-methyl labels for use in X-ray crystallography.
    J. Am. Chem. Soc.  2005, 127, 12035-12045.

    A. Serganov, S. Keiper, L. Malinina, V. Tereshko, E. Skripkin, C. Höbartner, A. Polonskaia, A. T. Phan, R. Wombacher, R. Micura, Z. Dauter, A. Jäschke, D. J. Patel, Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.
    Nat. Struct. Mol. Biol.  2005, 12, 218-224. SI

               comments by others
                 News and views: JN Pitt, A. Ferré-d'Amare, Nat. Struct. Mol. Biol.  2005, 12, 206-208.

    2004

    A. Serganov, Y. R. Yuan, O. Pikovskaya, A. Polonskaia, L. Malinina, A.T. Phan, C. Höbartner, R. Micura, R.R. Breaker, D.J. Patel, Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs.
    Chem. Biol.  2004, 11, 1729-1741.

               comments by others
                 Comment: A. Lescoute, E. Westhof, Chem. Biol.  2005, 12, 10-13.

    C. Höbartner, H. Mittendorfer, K. Breuker, R. Micura, Triggering of RNA secondary structures by a functionalized nucleobase.
    Angew. Chem.  2004, 116, 4012-4015; Angew. Chem. Int. Ed.  2004, 43, 3922-3925. SI

    2003

    R. Micura and C. Höbartner, On secondary structure rearrangements and equilibria of small RNAs.
    ChemBioChem  20034, 984-990.

    C. Höbartner, C. Kreutz, E. Flecker, E. Ottenschläger, W. Pils, K. Grubmayr, R. Micura, The synthesis of 2'-O -[(triisopropylsilyl)oxy]methyl (TOM) phosphoramidites of methylated ribonucleosides (m1G, m2G, m22G, m1I, m3U, m4C, m6A, m62A) for use in automated RNA solid-phase synthesis.Monatshefte für Chemie - Chemical Monthly  2003134, 851-873.

    C. Höbartner, R. Micura, Bistable secondary structures of small RNAs and their structural probing by comparative imino proton NMR spectroscopy.
    J. Mol. Biol.  2003325, 421-431.

    2002

    C. Höbartner, M.-O. Ebert, B. Jaun, R. Micura, RNA two-state conformation equilibria and the effect of nucleobase methylation.
    Angew. Chem.  2002114, 619-623; Angew. Chem. Int. Ed.  200241, 605-609.

    2001

    R. Micura, W. Pils, C. Höbartner, K. Grubmayr, M.-O. Ebert, B. Jaun, Methylation of nucleobases in RNA oligonucleotides mediates hairpin-duplex conversion.
    Nucleic Acids Res.  200129, 3977-4005.

    2000

    A. Stutz, C. Höbartner, S. Pitsch, Novel fluoride-labile nucleobase-protecting groups for the synthesis of 3'(2')-O -aminoacylated RNA sequences.
    Helv. Chim. Acta  200083, 2477-2503.

    Buchkapitel

    F. Javadi-Zarnaghi, C. Höbartner, Strategies for Characterization of Enzymatic Nucleic Acids. In: Advances in Biochemical Engineering/Biotechnology. Springer, Berlin, Heidelberg 2017, 1-22. 

    C. Höbartner, L. Büttner, F. Javadi-Zarnaghi, Bioorthogonal modifications and cycloaddition reactions for RNA Chemical Biology, in RNA Structure and Folding (Eds. D. Klostermeier, C. Hammann). DeGruyter 2013, 75-99. ISBN 978-3110284591

    P.I. Pradeepkumar, C. Höbartner, RNA-Cleaving DNA enzymes and their potential therapeutic applications as antibacterial and antiviral agents, in From Nucleic Acids Sequences to Molecular Medicine (Eds. V. Erdmann, J. Barciszewski), Springer, 2012, 371-410. ISBN 978-3-642-27425-1

    C. Höbartner, P.I. Pradeepkumar, DNA catalysts for synthetic applications in biomolecular chemistry, in New strategies in chemical synthesis and catalysis (Ed. B. Pignataro), Wiley-VCH, 2012, 129-155. ISBN 978-3-527-33090-4

    C. Höbartner, Chemical Synthesis of RNA, in Alternative pre-mRNA splicing: Theory and Protocols (Eds. S. Stamm, C. Smith, R. Lührmann), Wiley-VCH, 2012, 155-163. ISBN 3-527-32606-5

    C. Höbartner, F. Wachowius, Chemical synthesis of modified RNA, in The Chemical Biology of Nucleic Acids (Ed. G. Mayer), Wiley, 2010, 1-37. ISBN: 978-0-470-51974-5

    R. Micura and C. Höbartner, Equilibria of RNA secondary structures, in Highlights in Bioorganic Chemistry, Methods and Applications (Ed. C. Schmuck, H. Wennemers) Wiley-VCH, Weinheim, 2004, 3-16.

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