Prof. Dr. C. Höbartner

Prof. Dr. Claudia Höbartner

Universität Würzburg
Institut für Organische Chemie and
Center for Nanosystems Chemistry
Am Hubland
97074 Würzburg

Phone: +49 931 31-89693
Fax: +49 931 31-84755
claudia.hoebartner@uni-wuerzburg.de

Administrative Assistant

Lisa Weidner

Phone: +49 931 31-87194
l-oc1.chemie@uni-wuerzburg.de

Welcome

Explore with us the exciting chemistry of nucleic acids! We synthesize chemically modified DNA and RNA, develop DNA catalysts, ribozymes and RNA aptamers, and explore their functions and innovative applications at the interface of chemistry and biology.

The crystal structure of the methyltransferase ribozyme MTR1 provides mechanistic insights into RNA-catalyzed RNA methylation. Published in Nat Chem Biol, 2022.

Just Published

H. Neitz and C. Höbartner. A tolane-modified 5-ethynyluridine as a universal and fluorogenic photochemical DNA crosslinker. Chem Commun. 2023 Sep 20. doi: 10.1039/d3cc03796g.

T. Okuda, A.-K. Lenz, F. Seitz, J. Vogel, C. Höbartner. A SAM analogue-utilizing ribozyme for site-specific RNA alkylation in living cells, Nat. Chem. 2023, published online September 4, 2023

C. P. M. Scheitl, T. Okuda, J. Adelmann, C. Höbartner
Ribozyme-Catalyzed Late-Stage Functionalization and Fluorogenic Labeling of RNA
Angew. Chem. Int. Ed 2023, published June 6, 2023

J. Dietzsch, A. Jayachandran, S. Mueller, C. Höbartner, T. Brixner, Excitonic coupling of RNA-templated merocyanine dimer studied by higher-order transient absorption spectroscopyChem. Commun. 2023, May 23.

H. Neitz, I. Bessi, J. Kuper, C. Kisker, C. Höbartner
Programmable DNA Interstrand Crosslinking by Alkene–Alkyne [2 + 2] Photocycloaddition
J. Am. Chem. Soc. 2023, 145, 9428–9433

H. Neitz, I. Bessi, V. Kachler, M. Michel, C. Höbartner
Tailored Tolane-Perfluorotolane Assembly as Supramolecular Base Pair Replacement in DNA
Angew. Chem. Int. Ed. 2023, 62, e202214456.

News

Poster Prize for Julia Dietzsch at the CMMC Symposium

Congratulations! Julia Dietzsch is among the three poster awardees at the CMMC Symposium 2023 in Molecular Medicine!

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Nucleinsäurechemietreffen 2023

Zum XI. Nucleinsäurechemietreffen der DNG am 14.-15.9.2023 versammelten sich ca 120 Teilnehmer an der Universität Würzburg um sich über ihre neuesten Forschungsergebnisse auszutauschen. Neben zwölf spannenden Vorträgen gab es 64 Posterbeiträge, von denen elf in Kurzvorträgen vorgestellt wurden. Nach den lebhaften Postersessions wurden fünf Posterpreisgewinner von allen Teilnehmern gewählt.

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SAMURI targets a specific adenosine in RNA

We report the ribozyme SAMURI which uses a synthetic SAM analogue as cofactor to make RNA in cells accessible for labeling by Click Chemistry. Just published in Nature Chemistry. Congrats to Takumi Okuda and all coauthors!

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Hubland Süd, Geb. C1

THE HÖBARTNER GROUP: ORGANIC AND BIOMOLECULAR CHEMISTRY

Welcome

Just Published

News

Poster Prize for Julia Dietzsch at the CMMC Symposium

Nucleinsäurechemietreffen 2023

SAMURI targets a specific adenosine in RNA

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