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Intern
    THE HÖBARTNER GROUP: ORGANIC AND BIOMOLECULAR CHEMISTRY

    Nucleic Acid Assemblies

    Nucleic acid merocyanine dimers

    Exciton coupling between two or more chromophores in a specific environment is a key mechanism associated with color tuning and modulation of absorption energies. Barbituric acid merocyanine (BAM) nucleosides in synthetic nucleic acid nanostructures show exciton coupling that can be tuned by the double helix conformation. Duplexes with different backbone constitutions and geometries afford different mutual dye arrangements, leading to distinct optical signatures seen in absorption, CD and fluorescence spectroscopy.


    J. Dietzsch, D. Bialas, J. Bandorf, F. Würthner, C. Höbartner
    Tuning exciton coupling of merocyanine nucleoside dimers by RNA, DNA and GNA double helix conformations
    Angew. Chem. Int. Ed. 2022.

    Bioorthogonal dipolar recognition

    Inspired by natural Watson-Crick base pairing and genetic code expansion by hydrophobic base pairing, we explore dipolar and quadrupolar stacking interactions as bioorthogonal elements for the assembly of supramolecular nucleic acid structures.

     

    Stay tuned for upcoming results on arene - fluoroarene recognition within the nucleic acid double helix.