Intern
THE BRINGMANN GROUP: BIOACTIVE COMPOUNDS FROM NATURE

Contact:

Prof. Dr. Dr. h.c. mult. Gerhard Bringmann

Institut für Organische Chemie
Am Hubland
97074 Würzburg, Germany

Phone: +49 931 31 85323
Fax: +49 931 31 84755
bringman@chemie.uni-wuerzburg.de

Our group pursues natural products chemistry with structural, biosynthetic, and pharmacological facets. We approach this topic in a broad, highly interdisciplinary way, applying – and, in part, newly developing – novel efficient methods of analytical, synthetic, computational, and medicinal chemistry.

Our special interest is devoted to stereochemical questions of stereogenic centers (C- or N-based), axes (C,C or C,N, sp2-sp2 or sp2-sp3), of chiral ‘planes’ or helices, both analytically and synthetically, and we test and optimize their bioactivities. Starting from rewarding sources (mostly tropical plants), we search for novel antiparasitic, antileukemic, and anticancer natural products including the elucidation of their full absolute stereostructures. Using biomimetic or non-biomimetic strategies, we elaborate synthetic pathways to the most rewarding metabolites; as an example, we have developed the 'lactone method' for the atropo-selective construction of highly hindered axially chiral biaryl and hetero-biaryl systems of any desired configuration.

 

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Just published

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B. K. Lombe, T. Bruhn, D. Feineis, V. Mudogo, R. Brun, G. Bringmann; Antiprotozoal spiro-Mbandakamines A1 and A2, Fused Naphthylisoquinoline Dimers from a Congolese Ancistrocladus PlantOrg. Lett. 2017, DOI: 10.1021/acs.orglett.7b03473.   

For more publications of the Bringmann Group, please visit our publications section

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Kontakt

Lehrstuhl für Organische Chemie I
Am Hubland
97074 Würzburg

Tel.: +49 931 31-85322
Fax: +49 931 31-84755
E-Mail

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