Research Interests

Motivated by a specific interest in regenerative medicine, our research activities focus on the design novel engineered therapeutic proteins to develop bioresponsive drug release systems, releasing drugs as a result of an external, biochemical stimulus in diseased tissues.  In the field of protein formulation, we explore novel and innovative methods to gain further insights into protein stability and sites of modification at the molecular level.

Methods and Techniques

Recombinant, synthetic and semi-synthetic peptide and protein synthesis, genetic code expansion, site-specific protein modification, bioorthogonal chemistries, PEGylation, bioresponsive drug delivery, mass spectrometr.

Key Publications

T. Lühmann et. al., Org. Biomol. Chem. 2016, 14(13), 334−59, A Perfluoroaromatic Abiotic Analog of H2 Relaxin Enabled by Rapid Flow-Based Peptide Synthesis
DOI: 10.1039/C6OB00208K

S. Sevim et. al., ACS Biomater. Sci. Eng. 2017, 3(6), 1000–1007, Nanomechanics on FGF-2 and heparin reveal slip bond characteristics with pH dependency
DOI: 10.1021/acsbiomaterials.6b00723

J. Ritzer, T. Lühmann et. al., Nat. Commun. 2017, 8 (1), 264, Diagnosing peri-implant disease using the tongue as a 24/7 detector
DOI:  10.1038/s41467-017-00340-x

CV of Priv.-Doz. Dr. Tessa Lühmann


Habilitation, Faculty of Chemistry and Pharmacy, University of Würzburg


Research Scholar, Prof. Bradley Pentelute, Department of Chemistry, MIT, Cambridge

Since 2011

Junior Research Group Leader, Institute of Pharmacy, Chair of Pharmaceutics and  Biopharmacy, University of Würzburg


Postdoctoral work with Prof. Viola Vogel and Prof. Bradley Nelson, ETH Zürich


PhD with Prof. Viola Vogel, ETH Zürich


Studies of biochemistry (University of Leipzig and ETH Zürich)
Diploma thesis with Prof. Annette Beck-Sickinger (University of Leipzig)


Background and Motivation

With a strong background in the synthesis of peptides and proteins, we aim at translating Nature´s design strategies into bioresponsive drug delivery platforms and diagnostic systems.


Priv-Doz. Dr. Tessa Lühmann

Phone: +49 931 31-82807