Key Research Interests
We investigate drugs in polymer matrices as well as biologically relevant environments by approaching the subject from different angles making use of the versatile toolbox of NMR spectroscopy in combination with other complementary techniques:
(1) A thorough understanding of the drug molecules and their interactions in the solid state and in solution as well as (2) the synthesis and analysis of different polymer platforms/hydrogels will be the foundation for (3) the study of the interactions of these drugs with the surrounding matrix and their subsequent release. Based on these insights, more specific polymers can be designed and (4) the response of stimuli-sensitive and degradable polymers can be monitored.
Methods and Techniques: 1D and 2D NMR in isotropic solutions & in anisotropic environments, diffusion NMR, solid-state NMR at moderate and fast MAS in combination with DFT calculations and diffraction methods, DSC, TGA.