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THE SEIBEL GROUP: ORGANIC AND BIOLOGICAL CHEMISTRY

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Christine Sternstein and a team at the University of Wuerzburg synthesized a new azido-functionalized S1P derivative that can be labeled via click chemistry with alkyne-substituted molecules.

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Die Zellen in der oberen Reihe wurden mit dem Fluoxetin-ähnlichen Molekül AKS466 behandelt und danach mit SARS-CoV-2 infiziert. Die Zellen unten wurden nur infiziert; in ihnen ist deutlich mehr virale RNA nachweisbar (hellere Punkte).

Completely unexpectedly, the enzyme ceramidase emerges as a new target structure for the therapy of SARS-CoV-2 infections. This is reported by Würzburg researchers in "Cells".

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A standard drug for the treatment of depression might also be effective against Covid-19, a new study by Würzburg virologists and chemists shows which has been published on a preprint server.

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Chemists and virologists from the University of Würzburg are currently testing substances on a large scale to fight the new coronavirus. Some of them have been proven surprisingly effective.

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For the first time ever, expansion microscopy allows the imaging of even the finest details of cell membranes. This offers new insights into bacterial and viral infection processes.

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The use of antibiotics also leads to multidrug-resistant bacteria. A new Research Training Group at the University of Würzburg will provide 14 doctoral training positions to develop alternatives to antibiotic treatment.

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Chemists have modified the enzyme levansucrase using a new method. The enzyme can now produce sugar polymers that are exciting for applications in the food industry and medicine.

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"From the basics of biofabrication to functional tissue models" – hence the title of a new Transregio Collaborative Research Centre headed by the University of Würzburg.

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Scientists from Würzburg have synthesized a complex sugar molecule which specifically binds to the tumor protein Galectin-1. This could help to recognize tumors at an early stage and to combat them in a targeted manner.

 

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