Intern
  • Theodor-Boveri-Institut
Biochemie

Publikationen

2025[ to top ]
  • Bartuli, J., Jungwirth, S., Dixit, M., Okuda, T., Zimmermann, J.P., Erlacher, M., Pan, T., Volz, A., Hüttenhofer, A., Warscheid, B., Höbartner, C., Grimm, C., Fischer, U., 2025. tRNA as an assembly chaperone for a macromolecular transcription-processing complex. Nature Structural & Molecular Biology. https://doi.org/10.1038/s41594-025-01653-y
  • Chen, W.W., Rodrigues, T.A., Wendscheck, D., Pedrosa, A.G., Yang, C., Francisco, T., Möcklinghoff, T., Zografakis, A., Nunes-Silva, B., Avraham, R.E., Silva, A.R., Ferreira, M.J., Das, H., Koster, J., Neuwirth, S., Bender, J., Oeljeklaus, S., Sondhi, V., Gatsogiannis, C., Schuldiner, M., Zalckvar, E., Hofmann, K., Waterham, H.R., DeBerardinis, R.J., Azevedo, J.E., Warscheid, B., 2025. PEX39 facilitates the peroxisomal import of PTS2-containing proteins. Nature Cell Biology 27, 1256–1271. https://doi.org/10.1038/s41556-025-01711-z
  • Yang, W., Cong, S., Li, R., Schwarz, J., Schulze, T., Gevelhoff, R.A., Chen, X., Ullrich, S., Falkenstein, K., Ott, D., Eixmann, P., Trentino, A., Thien, A., Heidmann, T., Schulze, E., Warscheid, B., Baumeister, R., Qi, W., 2025. Opposing roles of pseudokinases NRBP1 and NRBP2 in regulating L1 retrotransposition. Nature Communications 16, 6327. https://doi.org/10.1038/s41467-025-61626-z
  • Cruz-Zaragoza, L.D., Dahal, D., Koschel, M., Boshnakovska, A., Zheenbekova, A., Yilmaz, M., Morgenstern, M., Dohrke, J.-N., Bender, J., Valpadashi, A., Henningfeld, K.A., Oeljeklaus, S., Kremer, L.S., Breuer, M., Urbach, O., Dennerlein, S., Lidschreiber, M., Jakobs, S., Warscheid, B., Rehling, P., 2025. Silencing mitochondrial gene expression in living cells. Science 389. https://doi.org/10.1126/science.adr3498
  • Körner, M., Müller, P., Das, H., Kraus, F., Pfeuffer, T., Spielhaupter, S., Oeljeklaus, S., Schülein-Völk, C., Harper, J.W., Warscheid, B., Buchberger, A., 2025. p97/VCP is required for piecemeal autophagy of aggresomes. Nature Communications 16, 4243. https://doi.org/10.1038/s41467-025-59556-x
  • Wang, Z., Cao, G., Collier, M.P., Qiu, X., Broadway-Stringer, S., Šaman, D., Ng, J.Z.Y., Sen, N., Azad, A.J., Hooper, C., Zimmermann, J., McDonough, M.A., Brem, J., Rabe, P., Song, H., Alderson, T.R., Schofield, C.J., Bolla, J.R., Djinovic-Carugo, K., Fürst, D.O., Warscheid, B., Degiacomi, M.T., Allison, T.M., Hochberg, G.K.A., Robinson, C.V., Gehmlich, K., Benesch, J.L.P., 2025. Filamin C dimerisation is regulated by HSPB7. Nature Communications 16, 4090. https://doi.org/10.1038/s41467-025-58889-x
  • Kiani, A., Pierotti, C.L., Schedel, F., Kokot, T., Weyershaeuser, J., Brehm, M., Rios, P., Fehrenbach, K., Warscheid, B., Minguet, S., Schamel, W.W., Köhn, M., 2025. Development of a Peptide Inhibitor Targeting the C‐SH2 Domain of the SHP2 Phosphatase. ChemBioChem 26. https://doi.org/10.1002/cbic.202400938
  • Krishna, C.K., Das, H., Hohnen, L., Schliebs, W., Oeljeklaus, S., Warscheid, B., Kalel, V.C., Erdmann, R., 2025. High-confidence glycosomal membrane protein inventory unveils trypanosomal peroxin PEX15. Cell Reports 44, 115614. https://doi.org/10.1016/j.celrep.2025.115614
  • Linke, V., Chodkowski, M., Kaszuba, K., Radkiewicz, M., Schrader, T.A., Das, H., Rana, V., Stadnik, D., Dadlez, M., Warscheid, B., Schrader, M., Chacinska, A., 2025. Integrated proteome and lipidome analyses place OCIAD1 at the mitochondria–peroxisome intersection balancing lipid metabolism. Journal of Cell Science 138. https://doi.org/10.1242/jcs.263729
  • Özdemir, M., Oeljeklaus, S., Schendzielorz, A., Morgenstern, M., Valpadashi, A., Yousefi, R., Warscheid, B., Dennerlein, S., 2025. Definition of the human mitochondrial TOM interactome reveals TRABD as a new interacting protein. Journal of Cell Science 138. https://doi.org/10.1242/jcs.263576
  • Kosir, T., Das, H., Pilegaard Pedersen, M., Richard, A.-K., Anteghini, M., Dos Santos, V.M., Oeljeklaus, S., Van Der Klei, I.J., Warscheid, B., 2025. Integrative Omics reveals changes in the cellular landscape of peroxisome-deficient pex3 yeast cells. Microbial Cell 12, 9–33. https://doi.org/10.15698/mic2025.02.842
  • Jetishi, C., Aeschlimann, S., Schimanski, B., Käser, S., Mullner, R., Oeljeklaus, S., Akiyoshi, B., Warscheid, B., Butter, F., Schneider, A., Ochsenreiter, T., 2025. Connecting basal body and mitochondrial DNA: TAC53 and the tubular organization of the tripartite attachment complex. PLOS Pathogens 21, 1–23. https://doi.org/10.1371/journal.ppat.1013521
2024[ to top ]
  • von Känel, C., Oeljeklaus, S., Wenger, C., Stettler, P., Harsman, A., Warscheid, B., Schneider, A., 2024. Intermembrane Space-Localized TbTim15 Is an Essential Subunit of the Single Mitochondrial Inner Membrane Protein Translocase of Trypanosomes.. Molecular microbiology. https://doi.org/10.1111/mmi.15262
  • Wang, Z., Cao, G., Collier, M.P., Qiu, X., Broadway-Stringer, S., v Saman, D., Ng, J.Z., Sen, N., Azad, A.J., Hooper, C., Zimmermann, J., McDonough, M., Brem, J., Rabe, P., Song, H., Reid Alderson, T., Schofield, C.J., Bolla, J.R., Djinovic-Carugo, K., Fürst, D.O., Warscheid, B., Degiacomi, M.T., Allison, T.M., Hochberg, G.K., Robinson, C.V., Gehmlich, K., Benesch, J.L., 2024. Cardiac stress leads to regulation of Filamin C dimerisation via an ancient phosphorylation-modulated interaction with HSPB7. bioRxiv. https://doi.org/10.1101/2024.01.05.574393
  • Oeljeklaus, S., Sharma, L., Bender, J., Warscheid, B., 2024. Mass spectrometry-based proteomics to study mutants and interactomes of mitochondrial translocation proteins, in: Mitochondrial Translocases Part B. Elsevier, pp. 101–152. https://doi.org/10.1016/bs.mie.2024.07.059
  • Poerschke, S., Oeljeklaus, S., Cruz-Zaragoza, L.D., Schenzielorz, A., Dahal, D., Hillen, H.S., Das, H., Kremer, L.S., Valpadashi, A., Breuer, M., Sattmann, J., Richter-Dennerlein, R., Warscheid, B., Dennerlein, S., Rehling, P., 2024. Identification of TMEM126A as OXA1L-interacting Protein Reveals Cotranslational Quality Control in Mitochondria.. Molecular cell 84, 345–358.e5. https://doi.org/10.1016/j.molcel.2023.12.013
  • Kokot, T., Zimmermann, J.P., Schwäble, A.N., Reimann, L., Herr, A.L., Höfflin, N., Köhn, M., Warscheid, B., 2024. Protein phosphatase-1 regulates the binding of filamin C to FILIP1 in cultured skeletal muscle cells under mechanical stress. Scientific Reports 14, 27348. https://doi.org/10.1038/s41598-024-78953-8
  • Steinmetz, T.D., Thomas, J., Reimann, L., Himmelreich, A.-K., Schulz, S.R., Golombek, F., Castiglione, K., Jäck, H.-M., Brodesser, S., Warscheid, B., Mielenz, D., 2024. Identification of TFG- and Autophagy-Regulated Proteins and Glycerophospholipids in B Cells.. Journal of proteome research 23, 1615–1633. https://doi.org/10.1021/acs.jproteome.3c00713
  • Jonak, K., Suppanz, I., Bender, J., Chacinska, A., Warscheid, B., Topf, U., 2024. Ageing-Dependent Thiol Oxidation Reveals Early Oxidation of Proteins with Core Proteostasis Functions.. Life science alliance 7. https://doi.org/10.26508/lsa.202302300
  • von Känel, C., Stettler, P., Esposito, C., Berger, S., Amodeo, S., Oeljeklaus, S., Calderaro, S., Durante, I.M., Rašková, V., Warscheid, B., Schneider, A., 2024. Pam16 and Pam18 were repurposed during Trypanosoma brucei evolution to regulate the replication of mitochondrial DNA. PLOS Biology 22, 1–33. https://doi.org/10.1371/journal.pbio.3002449
  • Kokot, T., Zimmermann, J.P., Chand, Y., Krier, F., Reimann, L., Scheinost, L., Höfflin, N., Esch, A., Höhfeld, J., Warscheid, B., Köhn, M., 2024. Identification of phosphatases that dephosphorylate the co-chaperone BAG3. Life Science Alliance 8, e202402734. https://doi.org/10.26508/lsa.202402734
  • Zerbes, R.M., Colina-Tenorio, L., Bohnert, M., von der Malsburg, K., Peikert, C.D., Mehnert, C.S., Perschil, I., Klar, R.F.U., de Boer, R., Kram, A., van der Klei, I., Oeljeklaus, S., Warscheid, B., Rampelt, H., van der Laan, M., 2024. Coordination of cytochrome bc1 complex assembly at MICOS. EMBO Reports. https://doi.org/10.1038/s44319-024-00336-x
2023[ to top ]
  • Wenger, C., Harsman, A., Niemann, M., Oeljeklaus, S., von Känel, C., Calderaro, S., Warscheid, B., Schneider, A., 2023. The Mba1 Homologue of Trypanosoma Brucei Is Involved in the Biogenesis of Oxidative Phosphorylation Complexes.. Molecular microbiology 119, 537–550. https://doi.org/10.1111/mmi.15048
  • Das, H., Zografakis, A., Oeljeklaus, S., Warscheid, B., 2023. Analysis of Yeast Peroxisomes via Spatial Proteomics.. Methods in molecular biology (Clifton, N.J.) 2643, 13–31. https://doi.org/10.1007/978-1-0716-3048-8_2
  • Fischer, S., Bürgi, J., Gabay-Maskit, S., Maier, R., Mastalski, T., Yifrach, E., Obarska-Kosinska, A., Rudowitz, M., Erdmann, R., Platta, H.W., Wilmanns, M., Schuldiner, M., Zalckvar, E., Oeljeklaus, S., Drepper, F., Warscheid, B., 2023. Phosphorylation of the Receptor Protein Pex5p Modulates Import of Proteins into Peroxisomes.. Biological chemistry 404, 135–155. https://doi.org/10.1515/hsz-2022-0168
  • Fricke, A.L., Mühlhäuser, W.W.D., Reimann, L., Zimmermann, J.P., Reichenbach, C., Knapp, B., Peikert, C.D., Heberle, A.M., Faessler, E., Schäuble, S., Hahn, U., Thedieck, K., Radziwill, G., Warscheid, B., 2023. Phosphoproteomics Profiling Defines a Target Landscape of the Basophilic Protein Kinases AKT, S6K, and RSK in Skeletal Myotubes.. Journal of proteome research 22, 768–789. https://doi.org/10.1021/acs.jproteome.2c00505
  • Gerber, M., Suppanz, I., Oeljeklaus, S., Niemann, M., Käser, S., Warscheid, B., Schneider, A., Dewar, C.E., 2023. A Msp1-containing Complex Removes Orphaned Proteins in the Mitochondrial Outer Membrane of T. Brucei.. Life science alliance 6. https://doi.org/10.26508/lsa.202302004
  • Kim, M., Serwa, R.A., Samluk, L., Suppanz, I., Kodroń, A., Stk epkowski, T.M., Elancheliyan, P., Tsegaye, B., Oeljeklaus, S., Wasilewski, M., Warscheid, B., Chacinska, A., 2023. Immunoproteasome-Specific Subunit PSMB9 Induction Is Required to Regulate Cellular Proteostasis upon Mitochondrial Dysfunction.. Nature communications 14, 4092. https://doi.org/10.1038/s41467-023-39642-8
  • Xu, F., Li, R., von Gromoff, E.D., Drepper, F., Knapp, B., Warscheid, B., Baumeister, R., Qi, W., 2023. Reprogramming of the Transcriptome after Heat Stress Mediates Heat Hormesis in Caenorhabditis Elegans.. Nature communications 14, 4176. https://doi.org/10.1038/s41467-023-39882-8
  • Guhathakurta, S., Erdogdu, N.U., Hoffmann, J.J., Grzadzielewska, I., Schendzielorz, A., Seyfferth, J., Maa}rtensson, C.U., Corrado, M., Karoutas, A., Warscheid, B., Pfanner, N., Becker, T., Akhtar, A., 2023. COX17 Acetylation via MOF-KANSL Complex Promotes Mitochondrial Integrity and Function.. Nature metabolism 5, 1931–1952. https://doi.org/10.1038/s42255-023-00904-w
  • Becker, F., Fuchs, S., Refisch, L., Drepper, F., Bildl, W., Schulte, U., Liang, S., Heinicke, J.I., Hansen, S.C., Kreutz, C., Warscheid, B., Fakler, B., Mymrikov, E.V., Hunte, C., 2023. Conformational Regulation and Target-Myristoyl Switch of Calcineurin B Homologous Protein 3.. eLife 12. https://doi.org/10.7554/eLife.83868
2022[ to top ]
  • Iyer, A., Niemann, M., Serricchio, M., Dewar, C.E., Oeljeklaus, S., Farine, L., Warscheid, B., Schneider, A., Bütikofer, P., 2022. The Endoplasmic Reticulum Membrane Protein Complex Localizes to the Mitochondrial - Endoplasmic Reticulum Interface and Its Subunits Modulate Phospholipid Biosynthesis in Trypanosoma Brucei.. PLoS pathogens 18, e1009717. https://doi.org/10.1371/journal.ppat.1009717
  • Thuma, N., Döhler, D., Mielenz, D., Sticht, H., Radtke, D., Reimann, L., Warscheid, B., Voehringer, D., 2022. A Newly Identified Secreted Larval Antigen Elicits Basophil-Dependent Protective Immunity against N. Brasiliensis Infection.. Frontiers in immunology 13, 979491. https://doi.org/10.3389/fimmu.2022.979491
  • Kors, S., Hacker, C., Bolton, C., Maier, R., Reimann, L., Kitchener, E.J.A., Warscheid, B., Costello, J.L., Schrader, M., 2022. Regulating Peroxisome-ER Contacts via the ACBD5-VAPB Tether by FFAT Motif Phosphorylation and {{GSK3\($\beta$\)}}.. The Journal of cell biology 221. https://doi.org/10.1083/jcb.202003143
  • Dewar, C.E., Oeljeklaus, S., Wenger, C., Warscheid, B., Schneider, A., 2022. Characterization of a Highly Diverged Mitochondrial ATP Synthase F(o) Subunit in Trypanosoma Brucei.. The Journal of biological chemistry 298, 101829. https://doi.org/10.1016/j.jbc.2022.101829
  • Schimanski, B., Aeschlimann, S., Stettler, P., Käser, S., Gomez-Fabra Gala, M., Bender, J., Warscheid, B., Vögtle, F.-N., Schneider, A., 2022. P166 Links Membrane and Intramitochondrial Modules of the Trypanosomal Tripartite Attachment Complex.. PLoS pathogens 18, e1010207. https://doi.org/10.1371/journal.ppat.1010207
  • Pinter, N., Glätzer, D., Fahrner, M., Fröhlich, K., Johnson, J., Grüning, B.A., Warscheid, B., Drepper, F., Schilling, O., Föll, M.C., 2022. MaxQuant and MSstats in Galaxy Enable Reproducible Cloud-Based Analysis of Quantitative Proteomics Experiments for Everyone.. Journal of proteome research 21, 1558–1565. https://doi.org/10.1021/acs.jproteome.2c00051
  • Dewar, C.E., Oeljeklaus, S., Mani, J., Mühlhäuser, W.W.D., von Känel, C., Zimmermann, J., Ochsenreiter, T., Warscheid, B., Schneider, A., 2022. Mistargeting of Aggregation Prone Mitochondrial Proteins Activates a Nucleus-Mediated Posttranscriptional Quality Control Pathway in Trypanosomes.. Nature communications 13, 3084. https://doi.org/10.1038/s41467-022-30748-z
  • Dewar, C.E., Oeljeklaus, S., Mani, J., Mühlhäuser, W.W.D., von Känel, C., Zimmermann, J., Ochsenreiter, T., Warscheid, B., Schneider, A., 2022. Mistargeting of aggregation prone mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes. Nature Communications 13, 3084. https://doi.org/10.1038/s41467-022-30748-z
2021[ to top ]
  • Dannenmaier, S., Oeljeklaus, S., Warscheid, B., 2021. 2nSILAC for Quantitative Proteomics of Prototrophic Baker’s Yeast., in: Methods in Molecular Biology (Clifton, N.J.). United States, pp. 253–270. https://doi.org/10.1007/978-1-0716-1024-4_18
  • Landwehr, V., Milanov, M., Angebauer, L., Hong, J., Jüngert, G., Hiersemenzel, A., Siebler, A., Schmit, F., Öztürk, Y., Dannenmaier, S., Drepper, F., Warscheid, B., Koch, H.-G., 2021. The Universally Conserved ATPase YchF Regulates Translation of Leaderless mRNA in Response to Stress Conditions.. Frontiers in molecular biosciences 8, 643696. https://doi.org/10.3389/fmolb.2021.643696
  • Pfanner, N., Warscheid, B., Wiedemann, N., 2021. Author Correction: Mitochondrial Proteins: From Biogenesis to Functional Networks.. Nature reviews. Molecular cell biology 22, 367. https://doi.org/10.1038/s41580-021-00361-x
  • Rout, S., Oeljeklaus, S., Makki, A., Tachezy, J., Warscheid, B., Schneider, A., 2021. Determinism and Contingencies Shaped the Evolution of Mitochondrial Protein Import.. Proceedings of the National Academy of Sciences of the United States of America 118. https://doi.org/10.1073/pnas.2017774118
  • Kostan, J., Pavv siv c, M., Puv z, V., Schwarz, T.C., Drepper, F., Molt, S., Graewert, M.A., Schreiner, C., Sajko, S., van der Ven, P.F.M., Onipe, A., Svergun, D.I., Warscheid, B., Konrat, R., Fürst, D.O., Lenarv civ c, B., Djinovi’c}}-Carugo, K., 2021. Molecular Basis of F-actin Regulation and Sarcomere Assembly via Myotilin.. PLoS biology 19, e3001148. https://doi.org/10.1371/journal.pbio.3001148
  • Sponga, A., Arolas, J.L., Schwarz, T.C., Jeffries, C.M., Rodriguez Chamorro, A., Kostan, J., Ghisleni, A., Drepper, F., Polyansky, A., De Almeida Ribeiro, E., Pedron, M., Zawadzka-Kazimierczuk, A., Mlynek, G., Peterbauer, T., Doto, P., Schreiner, C., Hollerl, E., Mateos, B., Geist, L., Faulkner, G., Kozminski, W., Svergun, D.I., Warscheid, B., Zagrovic, B., Gautel, M., Konrat, R., Djinović-Carugo, K., 2021. Order from Disorder in the Sarcomere: FATZ Forms a Fuzzy but Tight Complex and Phase-Separated Condensates with \($\alpha$\)-Actinin.. Science advances 7. https://doi.org/10.1126/sciadv.abg7653
  • Christopher, J.A., Stadler, C., Martin, C.E., Morgenstern, M., Pan, Y., Betsinger, C.N., Rattray, D.G., Mahdessian, D., Gingras, A.-C., Warscheid, B., Lehtiö, J., Cristea, I.M., Foster, L.J., Emili, A., Lilley, K.S., 2021. Subcellular Proteomics.. Nature reviews. Methods primers 1, 32. https://doi.org/10.1038/s43586-021-00029-y
  • Egert, J., Brombacher, E., Warscheid, B., Kreutz, C., 2021. DIMA: Data-Driven Selection of an Imputation Algorithm.. Journal of proteome research 20, 3489–3496. https://doi.org/10.1021/acs.jproteome.1c00119
  • Barchiesi, A., Bazzani, V., Jabczynska, A., Borowski, L.S., Oeljeklaus, S., Warscheid, B., Chacinska, A., Szczesny, R.J., Vascotto, C., 2021. DNA Repair Protein APE1 Degrades Dysfunctional Abasic mRNA in Mitochondria Affecting Oxidative Phosphorylation.. Journal of molecular biology 433, 167125. https://doi.org/10.1016/j.jmb.2021.167125
  • Dannenmaier, S., Desroches Altamirano, C., Schüler, L., Zhang, Y., Hummel, J., Milanov, M., Oeljeklaus, S., Koch, H.-G., Rospert, S., Alberti, S., Warscheid, B., 2021. Quantitative Proteomics Identifies the Universally Conserved ATPase Ola1p as a Positive Regulator of Heat Shock Response in Saccharomyces Cerevisiae.. The Journal of biological chemistry 297, 101050. https://doi.org/10.1016/j.jbc.2021.101050
  • Schwarz, J.J., Grundmann, L., Kokot, T., Kläsener, K., Fotteler, S., Medgyesi, D., Köhn, M., Reth, M., Warscheid, B., 2021. Quantitative Proteomics Identifies PTP1B as Modulator of B Cell Antigen Receptor Signaling.. Life science alliance 4. https://doi.org/10.26508/lsa.202101084
  • Dennerlein, S., Poerschke, S., Oeljeklaus, S., Wang, C., Richter-Dennerlein, R., Sattmann, J., Bauermeister, D., Hanitsch, E., Stoldt, S., Langer, T., Jakobs, S., Warscheid, B., Rehling, P., 2021. Defining the Interactome of the Human Mitochondrial Ribosome Identifies SMIM4 and TMEM223 as Respiratory Chain Assembly Factors.. eLife 10. https://doi.org/10.7554/eLife.68213
  • Morgenstern, M., Peikert, C.D., Lübbert, P., Suppanz, I., Klemm, C., Alka, O., Steiert, C., Naumenko, N., Schendzielorz, A., Melchionda, L., Mühlhäuser, W.W.D., Knapp, B., Busch, J.D., Stiller, S.B., Dannenmaier, S., Lindau, C., Licheva, M., Eickhorst, C., Galbusera, R., Zerbes, R.M., Ryan, M.T., Kraft, C., Kozjak-Pavlovic, V., Drepper, F., Dennerlein, S., Oeljeklaus, S., Pfanner, N., Wiedemann, N., Warscheid, B., 2021. Quantitative High-Confidence Human Mitochondrial Proteome and Its Dynamics in Cellular Context.. Cell metabolism 33, 2464–2483.e18. https://doi.org/10.1016/j.cmet.2021.11.001
  • Höhfeld, J., Benzing, T., Bloch, W., Fürst, D.O., Gehlert, S., Hesse, M., Hoffmann, B., Hoppe, T., Huesgen, P.F., Köhn, M., Kolanus, W., Merkel, R., Niessen, C.M., Pokrzywa, W., Rinschen, M.M., Wachten, D., Warscheid, B., 2021. Maintaining Proteostasis under Mechanical Stress.. EMBO reports 22, e52507. https://doi.org/10.15252/embr.202152507
2020[ to top ]
  • Pacheu-Grau, D., Wasilewski, M., Oeljeklaus, S., Gibhardt, C.S., Aich, A., Chudenkova, M., Dennerlein, S., Deckers, M., Bogeski, I., Warscheid, B., Chacinska, A., Rehling, P., 2020. COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria.. Journal of molecular biology 432, 2067–2079. https://doi.org/10.1016/j.jmb.2020.01.036
  • Schummer, A., Maier, R., Gabay-Maskit, S., Hansen, T., Mühlhäuser, W.W.D., Suppanz, I., Fadel, A., Schuldiner, M., Girzalsky, W., Oeljeklaus, S., Zalckvar, E., Erdmann, R., Warscheid, B., 2020. Pex14p Phosphorylation Modulates Import of Citrate Synthase 2 Into Peroxisomes in Saccharomyces Cerevisiae.. Frontiers in cell and developmental biology 8, 549451. https://doi.org/10.3389/fcell.2020.549451
  • Gomkale, R., Cruz-Zaragoza, L.D., Suppanz, I., Guiard, B., Montoya, J., Callegari, S., Pacheu-Grau, D., Warscheid, B., Rehling, P., 2020. Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos.. Current biology : CB 30, 1119–1127.e5. https://doi.org/10.1016/j.cub.2020.01.024
  • von Känel, C., Muñoz-Gómez, S.A., Oeljeklaus, S., Wenger, C., Warscheid, B., Wideman, J.G., Harsman, A., Schneider, A., 2020. Homologue Replacement in the Import Motor of the Mitochondrial Inner Membrane of Trypanosomes.. eLife 9. https://doi.org/10.7554/eLife.52560
  • Reimann, L., Schwäble, A.N., Fricke, A.L., Mühlhäuser, W.W.D., Leber, Y., Lohanadan, K., Puchinger, M.G., Schäuble, S., Faessler, E., Wiese, H., Reichenbach, C., Knapp, B., Peikert, C.D., Drepper, F., Hahn, U., Kreutz, C., van der Ven, P.F.M., Radziwill, G., Djinovi’c}}-Carugo, K., Fürst, D.O., Warscheid, B., 2020. Phosphoproteomics Identifies Dual-Site Phosphorylation in an Extended Basophilic Motif Regulating FILIP1-mediated Degradation of Filamin-C.. Communications biology 3, 253. https://doi.org/10.1038/s42003-020-0982-5
  • Meyer, S.J., Böser, A., Korn, M.A., Koller, C., Bertocci, B., Reimann, L., Warscheid, B., Nitschke, L., 2020. Cullin 3 Is Crucial for Pro-B Cell Proliferation, Interacts with CD22, and Controls CD22 Internalization on B Cells.. Journal of immunology (Baltimore, Md. : 1950) 204, 3360–3374. https://doi.org/10.4049/jimmunol.1900925
  • Drepper, F., Biernat, J., Kaniyappan, S., Meyer, H.E., Mandelkow, E.M., Warscheid, B., Mandelkow, E., 2020. A Combinatorial Native MS and LC-MS/MS Approach Reveals High Intrinsic Phosphorylation of Human Tau but Minimal Levels of Other Key Modifications.. The Journal of biological chemistry 295, 18213–18225. https://doi.org/10.1074/jbc.RA120.015882
  • Lill, P., Hansen, T., Wendscheck, D., Klink, B.U., Jeziorek, T., Vismpas, D., Miehling, J., Bender, J., Schummer, A., Drepper, F., Girzalsky, W., Warscheid, B., Erdmann, R., Gatsogiannis, C., 2020. Towards the Molecular Architecture of the Peroxisomal Receptor Docking Complex.. Proceedings of the National Academy of Sciences of the United States of America 117, 33216–33224. https://doi.org/10.1073/pnas.2009502117
2019[ to top ]
  • Jauss, B., Petriman, N.-A., Drepper, F., Franz, L., Sachelaru, I., Welte, T., Steinberg, R., Warscheid, B., Koch, H.-G., 2019. Noncompetitive Binding of PpiD and YidC to the SecYEG Translocon Expands the Global View on the SecYEG Interactome in Escherichia Coli.. The Journal of biological chemistry 294, 19167–19183. https://doi.org/10.1074/jbc.RA119.010686
  • Kalel, V.C., Li, M., Gaussmann, S., Delhommel, F., Schäfer, A.-B., Tippler, B., Jung, M., Maier, R., Oeljeklaus, S., Schliebs, W., Warscheid, B., Sattler, M., Erdmann, R., 2019. Evolutionary Divergent PEX3 Is Essential for Glycosome Biogenesis and Survival of Trypanosomatid Parasites.. Biochimica et biophysica acta. Molecular cell research 1866, 118520. https://doi.org/10.1016/j.bbamcr.2019.07.015
  • Eichenberger, C., Oeljeklaus, S., Bruggisser, J., Mani, J., Haenni, B., Kaurov, I., Niemann, M., Zuber, B., Lukev s, J., Hashimi, H., Warscheid, B., Schimanski, B., Schneider, A., 2019. The Highly Diverged Trypanosomal MICOS Complex Is Organized in a Nonessential Integral Membrane and an Essential Peripheral Module.. Molecular microbiology 112, 1731–1743. https://doi.org/10.1111/mmi.14389
  • Fröbel, J., Blümmel, A.-S., Drepper, F., Warscheid, B., Müller, M., 2019. Surface-Exposed Domains of TatB Involved in the Structural and Functional Assembly of the Tat Translocase in Escherichia Coli.. The Journal of biological chemistry 294, 13902–13914. https://doi.org/10.1074/jbc.RA119.009298
  • Maartensson, C.U., Priesnitz, C., Song, J., Ellenrieder, L., Doan, K.N., Boos, F., Floerchinger, A., Zufall, N., Oeljeklaus, S., Warscheid, B., Becker, T., 2019. Mitochondrial Protein Translocation-Associated Degradation.. Nature 569, 679–683. https://doi.org/10.1038/s41586-019-1227-y
  • Pfanner, N., Warscheid, B., Wiedemann, N., 2019. Mitochondrial Proteins: From Biogenesis to Functional Networks.. Nature reviews. Molecular cell biology 20, 267–284. https://doi.org/10.1038/s41580-018-0092-0
  • El Magraoui, F., Brinkmeier, R., Mastalski, T., Hupperich, A., Strehl, C., Schwerter, D., Girzalsky, W., Meyer, H.E., Warscheid, B., Erdmann, R., Platta, H.W., 2019. The Deubiquitination of the PTS1-import Receptor Pex5p Is Required for Peroxisomal Matrix Protein Import.. Biochimica et biophysica acta. Molecular cell research 1866, 199–213. https://doi.org/10.1016/j.bbamcr.2018.11.002
  • Hörner, M., Eble, J., Yousefi, O.S., Schwarz, J., Warscheid, B., Weber, W., Schamel, W.W.A., 2019. Light-Controlled Affinity Purification of Protein Complexes Exemplified by the Resting ZAP70 Interactome.. Frontiers in immunology 10, 226. https://doi.org/10.3389/fimmu.2019.00226
2018[ to top ]
  • Klümper, J., Oeljeklaus, S., Warscheid, B., Erdmann, R., Schliebs, W., 2018. Using Pull Down Strategies to Analyze the Interactome of Peroxisomal Membrane Proteins in Human Cells.. Sub-cellular biochemistry 89, 261–285. https://doi.org/10.1007/978-981-13-2233-4_11
  • Yifrach, E., Fischer, S., Oeljeklaus, S., Schuldiner, M., Zalckvar, E., Warscheid, B., 2018. Defining the Mammalian Peroxisomal Proteome.. Sub-cellular biochemistry 89, 47–66. https://doi.org/10.1007/978-981-13-2233-4_2
  • Topf, U., Suppanz, I., Samluk, L., Wrobel, L., Böser, A., Sakowska, P., Knapp, B., Pietrzyk, M.K., Chacinska, A., Warscheid, B., 2018. Quantitative Proteomics Identifies Redox Switches for Global Translation Modulation by Mitochondrially Produced Reactive Oxygen Species.. Nature communications 9, 324. https://doi.org/10.1038/s41467-017-02694-8
  • Petriman, N.-A., Jauß, B., Hufnagel, A., Franz, L., Sachelaru, I., Drepper, F., Warscheid, B., Koch, H.-G., 2018. The Interaction Network of the YidC Insertase with the SecYEG Translocon, SRP and the SRP Receptor FtsY.. Scientific reports 8, 578. https://doi.org/10.1038/s41598-017-19019-w
  • Lorenzi, I., Oeljeklaus, S., Aich, A., Ronsör, C., Callegari, S., Dudek, J., Warscheid, B., Dennerlein, S., Rehling, P., 2018. The Mitochondrial TMEM177 Associates with COX20 during COX2 Biogenesis.. Biochimica et biophysica acta. Molecular cell research 1865, 323–333. https://doi.org/10.1016/j.bbamcr.2017.11.010
  • González Montoro, A., Auffarth, K., Hönscher, C., Bohnert, M., Becker, T., Warscheid, B., Reggiori, F., van der Laan, M., Fröhlich, F., Ungermann, C., 2018. Vps39 Interacts with Tom40 to Establish One of Two Functionally Distinct Vacuole-Mitochondria Contact Sites.. Developmental cell 45, 621–636.e7. https://doi.org/10.1016/j.devcel.2018.05.011
  • Dannenmaier, S., Stiller, S.B., Morgenstern, M., Lübbert, P., Oeljeklaus, S., Wiedemann, N., Warscheid, B., 2018. Complete Native Stable Isotope Labeling by Amino Acids of Saccharomyces Cerevisiae for Global Proteomic Analysis.. Analytical chemistry 90, 10501–10509. https://doi.org/10.1021/acs.analchem.8b02557
  • Kaurov, I., Vancová, M., Schimanski, B., Cadena, L.R., Heller, J. rí, Bíl’y}}, T. s, Potv ev sil, D., Eichenberger, C., Bruce, H., Oeljeklaus, S., Warscheid, B., Zdráhal, Z. ek, Schneider, A., Lukev s, J., Hashimi, H., 2018. The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import.. Current biology : CB 28, 3393–3407.e5. https://doi.org/10.1016/j.cub.2018.09.008
  • Opaliński, L., Song, J., Priesnitz, C., Wenz, L.-S., Oeljeklaus, S., Warscheid, B., Pfanner, N., Becker, T., 2018. Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis.. Cell reports 25, 2036–2043.e5. https://doi.org/10.1016/j.celrep.2018.10.083
2017[ to top ]
  • Schummer, A., Fischer, S., Oeljeklaus, S., Warscheid, B., 2017. Study of Peroxisomal Protein Phosphorylation by Functional Proteomics.. Methods in molecular biology (Clifton, N.J.) 1595, 267–289. https://doi.org/10.1007/978-1-4939-6937-1_26
  • Callegari, S., Oeljeklaus, S., Warscheid, B., Dennerlein, S., Thumm, M., Rehling, P., Dudek, J., 2017. Phospho-Ubiquitin-PARK2 Complex as a Marker for Mitophagy Defects.. Autophagy 13, 201–211. https://doi.org/10.1080/15548627.2016.1254852
  • Fischer, A., Weber, W., Warscheid, B., Radziwill, G., 2017. AKT-dependent Phosphorylation of the SAM Domain Induces Oligomerization and Activation of the Scaffold Protein CNK1.. Biochimica et biophysica acta. Molecular cell research 1864, 89–100. https://doi.org/10.1016/j.bbamcr.2016.10.009
  • Hoffmann, L., Schummer, A., Reimann, J., Haurat, M.F., Wilson, A.J., Beeby, M., Warscheid, B., Albers, S.-V., 2017. Expanding the Archaellum Regulatory Network - the Eukaryotic Protein Kinases ArnC and ArnD Influence Motility of Sulfolobus Acidocaldarius.. MicrobiologyOpen 6. https://doi.org/10.1002/mbo3.414
  • Ruf, S., Heberle, A.M., Langelaar-Makkinje, M., Gelino, S., Wilkinson, D., Gerbeth, C., Schwarz, J.J., Holzwarth, B., Warscheid, B., Meisinger, C., van Vugt, M.A.T.M., Baumeister, R., Hansen, M., Thedieck, K., 2017. PLK1 (Polo like Kinase 1) Inhibits MTOR Complex 1 and Promotes Autophagy.. Autophagy 13, 486–505. https://doi.org/10.1080/15548627.2016.1263781
  • Reimann, L., Wiese, H., Leber, Y., Schwäble, A.N., Fricke, A.L., Rohland, A., Knapp, B., Peikert, C.D., Drepper, F., van der Ven, P.F.M., Radziwill, G., Fürst, D.O., Warscheid, B., 2017. Myofibrillar Z-discs Are a Protein Phosphorylation Hot Spot with Protein Kinase C (PKC α) Modulating Protein Dynamics.. Molecular & cellular proteomics : MCP 16, 346–367. https://doi.org/10.1074/mcp.M116.065425
  • Rampelt, H., Bohnert, M., Zerbes, R.M., Horvath, S.E., Warscheid, B., Pfanner, N., van der Laan, M., 2017. Mic10, a Core Subunit of the Mitochondrial Contact Site and Cristae Organizing System, Interacts with the Dimeric F(1)F(o)-ATP Synthase.. Journal of molecular biology 429, 1162–1170. https://doi.org/10.1016/j.jmb.2017.03.006
  • Peikert, C.D., Mani, J., Morgenstern, M., Käser, S., Knapp, B., Wenger, C., Harsman, A., Oeljeklaus, S., Schneider, A., Warscheid, B., 2017. Charting Organellar Importomes by Quantitative Mass Spectrometry.. Nature communications 8, 15272. https://doi.org/10.1038/ncomms15272
  • Mokada-Gopal, L., Boeser, A., Lehmann, C.H.K., Drepper, F., Dudziak, D., Warscheid, B., Voehringer, D., 2017. Identification of Novel STAT6-Regulated Proteins in Mouse B Cells by Comparative Transcriptome and Proteome Analysis.. Journal of immunology (Baltimore, Md. : 1950) 198, 3737–3745. https://doi.org/10.4049/jimmunol.1601838
  • Harsman, A., Oeljeklaus, S., Wenger, C., Huot, J.L., Warscheid, B., Schneider, A., 2017. Corrigendum: The Non-Canonical Mitochondrial Inner Membrane Presequence Translocase of Trypanosomatids Contains Two Essential Rhomboid-like Proteins.. Nature communications 8, 16123. https://doi.org/10.1038/ncomms16123
  • Morgenstern, M., Stiller, S.B., Lübbert, P., Peikert, C.D., Dannenmaier, S., Drepper, F., Weill, U., Höß, P., Feuerstein, R., Gebert, M., Bohnert, M., van der Laan, M., Schuldiner, M., Schütze, C., Oeljeklaus, S., Pfanner, N., Wiedemann, N., Warscheid, B., 2017. Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale.. Cell reports 19, 2836–2852. https://doi.org/10.1016/j.celrep.2017.06.014
  • Fischer, A., Mühlhäuser, W.W.D., Warscheid, B., Radziwill, G., 2017. Membrane Localization of Acetylated CNK1 Mediates a Positive Feedback on RAF/ERK Signaling.. Science advances 3, e1700475. https://doi.org/10.1126/sciadv.1700475
  • Wenger, C., Oeljeklaus, S., Warscheid, B., Schneider, A., Harsman, A., 2017. A Trypanosomal Orthologue of an Intermembrane Space Chaperone Has a Non-Canonical Function in Biogenesis of the Single Mitochondrial Inner Membrane Protein Translocase.. PLoS pathogens 13, e1006550. https://doi.org/10.1371/journal.ppat.1006550
  • Dolezal, E., Infantino, S., Drepper, F., Börsig, T., Singh, A., Wossning, T., Fiala, G.J., Minguet, S., Warscheid, B., Tarlinton, D.M., Jumaa, H., Medgyesi, D., Reth, M., 2017. The BTG2-PRMT1 Module Limits Pre-B Cell Expansion by Regulating the CDK4-Cyclin-D3 Complex.. Nature immunology 18, 911–920. https://doi.org/10.1038/ni.3774
  • Niemann, M., Harsman, A., Mani, J., Peikert, C.D., Oeljeklaus, S., Warscheid, B., Wagner, R., Schneider, A., 2017. tRNAs and Proteins Use the Same Import Channel for Translocation across the Mitochondrial Outer Membrane of Trypanosomes.. Proceedings of the National Academy of Sciences of the United States of America 114, E7679-E7687. https://doi.org/10.1073/pnas.1711430114
  • Wróblewska, J.P., Cruz-Zaragoza, L.D., Yuan, W., Schummer, A., Chuartzman, S.G., de Boer, R., Oeljeklaus, S., Schuldiner, M., Zalckvar, E., Warscheid, B., Erdmann, R., van der Klei, I.J., 2017. Saccharomyces Cerevisiae Cells Lacking Pex3 Contain Membrane Vesicles That Harbor a Subset of Peroxisomal Membrane Proteins.. Biochimica et biophysica acta. Molecular cell research 1864, 1656–1667. https://doi.org/10.1016/j.bbamcr.2017.05.021
  • Naumenko, N., Morgenstern, M., Rucktäschel, R., Warscheid, B., Rehling, P., 2017. INA Complex Liaises the F(1)F(o)-ATP Synthase Membrane Motor Modules.. Nature communications 8, 1237. https://doi.org/10.1038/s41467-017-01437-z
  • Krüger, V., Becker, T., Becker, L., Montilla-Martinez, M., Ellenrieder, L., Vögtle, F.-N., Meyer, H.E., Ryan, M.T., Wiedemann, N., Warscheid, B., Pfanner, N., Wagner, R., Meisinger, C., 2017. Identification of New Channels by Systematic Analysis of the Mitochondrial Outer Membrane.. The Journal of cell biology 216, 3485–3495. https://doi.org/10.1083/jcb.201706043
  • Käser, S., Willemin, M., Schnarwiler, F., Schimanski, B., Poveda-Huertes, D., Oeljeklaus, S., Haenni, B., Zuber, B., Warscheid, B., Meisinger, C., Schneider, A., 2017. Biogenesis of the Mitochondrial DNA Inheritance Machinery in the Mitochondrial Outer Membrane of Trypanosoma Brucei.. PLoS pathogens 13, e1006808. https://doi.org/10.1371/journal.ppat.1006808
  • Blümmel, A.-S., Drepper, F., Knapp, B., Eimer, E., Warscheid, B., Müller, M., Fröbel, J., 2017. Structural Features of the TatC Membrane Protein That Determine Docking and Insertion of a Twin-Arginine Signal Peptide.. The Journal of biological chemistry 292, 21320–21329. https://doi.org/10.1074/jbc.M117.812560
2016[ to top ]
  • Chan, A., Schummer, A., Fischer, S., Schröter, T., Cruz-Zaragoza, L.D., Bender, J., Drepper, F., Oeljeklaus, S., Kunau, W.-H., Girzalsky, W., Warscheid, B., Erdmann, R., 2016. Pex17p-Dependent Assembly of Pex14p/Dyn2p-subcomplexes of the Peroxisomal Protein Import Machinery.. European journal of cell biology 95, 585–597. https://doi.org/10.1016/j.ejcb.2016.10.004
  • Harsman, A., Oeljeklaus, S., Wenger, C., Huot, J.L., Warscheid, B., Schneider, A., 2016. The Non-Canonical Mitochondrial Inner Membrane Presequence Translocase of Trypanosomatids Contains Two Essential Rhomboid-like Proteins.. Nature communications 7, 13707. https://doi.org/10.1038/ncomms13707