Publications

Scheitl, C.P.M., Dorinova, E., Christopher, S., Walunj, M.B., Okuda, T., Sednev, M.V. & Höbartner, C.
An Unexpected Adenosine-Alkylating Ribozyme Emerged by Target Site Relocation during in Vitro Selection. 
Journal of the American Chemical Society
Published online November 20, 2025
►DOI: 10.1021/jacs.5c13970

Bartuli, J., Jungwirth, S., Dixit, M., Okuda, T., Zimmermann, P. J., Erlacher, M., Pan, T., Volz, A., Hüttenhofer, A., Warscheid, B., Höbartner, C., Grimm, C. & Fischer, U.
tRNA as an assembly chaperone for a macromolecular transcription-processing complex
Nature structural & molecular biology
Published online September 4, 2025
►DOI: 10.1038/s41594-025-01653-y

Chen, H-A. (co-first), Okuda, T. (co-first), Lenz, A. K., Scheitl, C. P. M., Schindelin, H. & Höbartner, C.
Structure and catalytic activity of the SAM utilizing ribozyme SAMURI 
Nature chemical biology
Published online January 8, 2025
►DOI: 10.1038/s41589-024-01808-w

Ishida, K., Kasahara, Y., Hoshino, H., Okuda, T., & Obika, S.
Systematic Analysis of 2'-O-Alkyl Modified Analogs for Enzymatic Synthesis and Their Oligonucleotide Properties
Molecules 2023, 28(23), 7911
Published online December 2, 2023
► DOI: 10.3390/molecules28237911

Okuda, T., Lenz, A.K., Seitz, F., Vogel, J. & Höbartner, C.
A SAM analogue-utilizing ribozyme for site-specific RNA alkylation in living cells
Nature Chemistry, 15, 1523–1531
Published online September 4, 2023
►DOI: 10.1038/s41557-023-01320-z

Scheitl, C.P.M., Okuda, T., Adelmann, J. & Höbartner, C.
Ribozyme-catalyzed late-stage functionalization and fluorogenic labeling of RNA
Angew. Chem. Int. Ed., 62, e202305463
Published online June 6, 2023
►DOI: 10.1002/anie.202305463

Uemachi, H., Kasahara, Y., Tanaka, K., Okuda, T., Yoneda, Y., Obika, S.
Hybrid-Type SELEX for the Selection of Artificial Nucleic Acid Aptamers Exhibiting Cell Internalization Activity
Pharmaceutics, 13, 888
Published online June 15, 2021
► DOI: 10.3390/pharmaceutics13060888

Tanaka, K., Okuda, T., Kasahara, Y., Obika, S.
Base-modified aptamers obtained by cell-internalization SELEX facilitate cellular uptake of an antisense oligonucleotide
Mol. Ther. Nucleic. Acids, 23, 440–449
Published online March 5, 2021
►DOI: 10.1016/j.omtn.2020.11.016

Uemachi, H., Kasahara, Y., Tanaka, K., Okuda, T., Yoneda, Y., Obika, S.
Discovery of cell-internalizing artificial nucleic acid aptamers for lung fibroblasts and targeted drug delivery
Bioorganic Chemistry, 105, 104321–104330
Published online December, 2020
►DOI: 10.1016/j.bioorg.2020.104321

Komine, H., Mori, S., Morihiro K., Ishida, K., Okuda, T., Kasahara, Y., Aoyama, H., Yamaguchi, T., Obika, S.
Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold
Molecules, 25, 1732–1747
Published online April 9, 2020
►DOI: 10.3390/molecules25071732

Okuda, T., Kawashima, Y., Kasahara, Y., Takagi, T., Yamamoto, J., Iwai, S., Obika, S.
Inhibiting guanine oxidation and enhancing excess-electron- transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene
Chem. Comm., 55, 14062–14065
Published online 2019
► DOI: 10.1039/c9cc06498b

Matsushita, K. (co-first), Okuda, T.(co-first), Mori, S. (co-first), Konno, M. (co-first), Eguchi,
H., Asai, A., Koseki, J., Iwagami, Y., Yamada, D., Akita, H., Asaoka, T., Noda, T., Kawamoto, K., Gotoh,
K., Kobayashi, S., Kasahara, Y., Morihiro,
K., Satoh, T., Doki, Y., Mori, M., Ishii, H., Obika, S.
A Hydrogen Peroxide Activatable Gemcitabine Prodrug for the Selective Treatment of Pancreatic Ductal Adenocarcinoma
ChemMedChem, 14, 1384–1391 (Front Cover)
Published Online June 17 2019
► DOI: 10.1002/cmdc.201900324

Fujii, A., Nakagawa, O., Kishimoto, Y., Okuda, T., Nakatsuji, Y., Nozaki, N., Kasahara, Y., Obika, S.
1,3,9-Triaza-2-oxophenoxazine: An Artificial Nucleobase Forming Highly Stable Self-Base Pairs with Three Ag^I Ions in a Duplex
Chem. Euro. J., 25, 7443–7448 (Front Cover)
Published Online March 6 2019
► DOI: 10.1002/chem.201900373

Tanaka, K., Kasahara, Y., Miyamoto, Y., Okuda, T., Kasai, T., Onodera, K., Kuwahara, M., Oka, M., Yoneda, Y., Obika, S.
Development of oligonucleotide-based antagonists of Ebola virus protein 24 inhibiting its interaction with karyopherin alpha 1
Org. Biomol. Chem., 16, 4456–4463
Published online 2018
► DOI: 10.1039/C8OB00706C

Mori, S., Morihiro, K., Okuda, T., Kasahara, Y., Obika, S.
Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides
boronated ASOs are promising tools to control target gene expression in a designated manner and as a prodrug-type nucleic acid therapeutic for selective disease treatmen
Chem. Sci., 5, 1112–1118 (Front Cover)
Published Online 2018
►DOI: 10.1039/C7SC04318J

Okuda, T., Mori, S., Kasahara, Y., Morihiro, K., Ikejiri, M., Miyashita, K., Obika, S.
Synthesis and properties of 4-(diarylmethylene)imidazolinone-conjugated fluorescent nucleic acids
Tetrahedron Lett., 57, 3129–3132
Published Online July 20 2016
► DOI: 10.1016/j.tetlet.2016.06.012

Kawaguchi, S., Minamida, Y., Okuda, T., Sato, Y., Saeki, T., Yoshimura, A., Nomoto, A., Ogawa, A.
Photoinduced synthesis of p-perfluoroalkylated phosphines from triarylphosphines and their application in the copper-free cross-coupling of acid chlorides and terminal alkynes
Adv. Synth. Catal., 357, 2509–2519
Published Online August 3 2015
► DOI: 10.1002/adsc.201500294