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Prof. Dr. Claudia Höbartner

Universität Würzburg
Institut für Organische Chemie and
Center for Nanosystems Chemistry
Am Hubland
97074 Würzburg

Phone: +49 931 31-89693
Fax: +49 931 31-84755
claudia.hoebartner@uni-wuerzburg.de

Administrative Assistant

Lisa Weidner

Phone: +49 931 31-87194
l-oc1.chemie@uni-wuerzburg.de

Welcome

Explore with us the exciting chemistry of nucleic acids! We synthesize chemically modified DNA and RNA, develop DNA catalysts, ribozymes and RNA aptamers, and explore their functions and innovative applications at the interface of chemistry and biology.

The crystal structure of the methyltransferase ribozyme MTR1 provides mechanistic insights into RNA-catalyzed RNA methylation. Published in Nat Chem Biol, 2022.

Just Published

J. Dietzsch, A. Jayachandran, S. Mueller, C. Höbartner, T. Brixner, Excitonic coupling of RNA-templated merocyanine dimer studied by higher-order transient absorption spectroscopyChem. Commun. 2023, May 23.

H. Neitz, I. Bessi, J. Kuper, C. Kisker, C. Höbartner
Programmable DNA Interstrand Crosslinking by Alkene–Alkyne [2 + 2] Photocycloaddition
J. Am. Chem. Soc. 2023, 145, 9428–9433

H. Neitz, I. Bessi, V. Kachler, M. Michel, C. Höbartner
Tailored Tolane-Perfluorotolane Assembly as Supramolecular Base Pair Replacement in DNA
Angew. Chem. Int. Ed. 2023, 62, e202214456.

C.P.M. Scheitl, M. Mieczkowski, H. Schindelin, C. Höbartner
Structure and mechanism of the methyltransferase ribozyme MTR1
Nat. Chem. Biol. 2022, 18, 547.555.

M. V. Sednev, A. Liaqat, C. Höbartner
High-Throughput Activity Profiling of RNA-Cleaving DNA Catalysts by Deoxyribozyme Sequencing (DZ-seq)
J. Am. Chem. Soc. 2022, 144, 2090-2094.

N. Kleiber, N. Lemus-Diaz, C. Stiller, M. Heinrichs, M. Mong-Quyen Mai, P. Hackert, R. Richter-Dennerlein, C. Höbartner, K. E. Bohnsack, M. T. Bohnsack
The RNA methyltransferase METTL8 installs m³C₃₂ in mitochondrial tRNAs^Thr/Ser(UCN) to optimise tRNA structure and mitochondrial translation
Nat. Commun. 2022, 13, 209.

News

Congratulations Dr. Seitz

On April 28th, 2023 Florian Seitz successfully defended his PhD on "Synthesis, enzymatic recognition and antiviral properties of modified purine nucleosides". Congratulations and all best wishes for a bright future!

Congratulations Dr. Stiller

On April 3rd, 2023 Carina Stiller successfully defended her PhD on "Synthesis and applications of modified nucleosides and RNA nucleotides". Congratulations and all best wishes for a bright future!

Leibniz Prize for Claudia Höbartner

Claudia Höbartner is being honoured for her outstanding research on the nucleic acids DNA and RNA: She receives the prestigious Leibniz Prize by the DFG.

THE HÖBARTNER GROUP: ORGANIC AND BIOMOLECULAR CHEMISTRY