D. Kaiser, J. M. Winne, M. E. Ortiz-Soto, J. Seibel, T. Anh Le, B. Engels

    Mechanistical insights into the bioconjugation
reaction of Triazolinediones with tyrosine

    J. Org. Chem., just accepted 


    M. Kraus, C. Grimm, J. Seibel

    Reversibility of a Point Mutation Induced Domain Shift: Expanding the Conformational Space of a Sucrose Phosphorylase

    Scientific Reports2018, 8, 10490.



    M. E. Ortiz-Soto, J. Ertl, J. Mut, J. Adelmann, T. A. Le, J. Shan, J. Teßmar, A. Schlosser, B. Engels, J. Seibel

    Product-oriented chemical surface modification of a levansucrase (SacB) via an ene-type reaction 

    Chem. Sci.2018, 9, 5312-5321.




    J. Fink, J. Seibel

    Click reactions with functional Sphingolipids

    Biol. Chem., accepted for publication



    M. Gutmann, A. Braun, J. Seibel, T. Lühmann

    Bioorthogonal modification of cell derived matrices by metabolic glyco-engineering

    ACS Biomaterials Science & Engineering2018, 4, 1300-1306.


    J. Seibel, C. Grimm, J. Bechold

    Mit Zucker gegen Bösartiges

    Nachrichten aus der Chemie 2018, 66 (1), 30-31.


    J. Becam, T. Walter, A. Burgert, J. Schlegel, M. Sauer, J. Seibel, A. Schubert-Unkmeir

    Antibacterial activity of ceramide and ceramide analogs against pathogenic Neisseria

    Scientific Reports 2017, 7, Article number: 17627 (2017)







    M. Kraus, C. Grimm, J. Seibel

    Switching enzyme specificity from phosphate to resveratrol glucosylation

    Chem. Commun.2017, 53, 12181 - 12184.

    C. Possiel, A. Bäuerle, J. Seibel

    A novel Chemoenzymatic route to a new class of Sucrose esters

    Eur. J. Org. Chem.2017, 6335–6337.

    ­­J. Görl, C. Possiel, C. Sotriffer, J. Seibel,

    Extending the Scope of GTFR Glucosylation Reactions with Tosylated Substrates for Rare Sugars Synthesis

    ChemBioChem201718, 2012-2015.



    M. Elena Ortiz-Soto, C. Possiel, J. Görl, A. Vogel, R. Schmiedel, J. Seibel

    Impaired coordination of nucleophile and increased hydrophobicity in the +1 subsite shift levansucrase activity towards transfructosylation

    Glycobiology201727, 755-765.



    N. Bertleff-Zieschang, J. Bechold, C. Grimm, M. Reutlinger, P. Schneider, G. Schneider, J. Seibel

    Exploring the structural space of galectin-1-ligand interaction

    ChemBioChem2017, 18, 1477-1481.


    T. Walter,  J. Schlegel,  A. Burgert, A. Kurz,  J. Seibel and M. Sauer

    Incorporation studies of clickable ceramides in Jurkat cell plasma membranes

    Chem. Commun2017, 53, 6836-6839.


    M. Ortiz-Soto, J. Seibel

    Molecular Engineering of Enzymes
    Applied Bioengineering: Innovations and Future Directions 2017

    Stephan Wawra, Philipp Fesel, Heidi Widmer, Malte Timm, Jürgen Seibel, Lisa Leson, Leona Kesseler, Robin Nostadt, Magdalena Hilbert, Gregor Langen & Alga Zuccaro
    The fungal-specific β-glucan-binding lectin FGB1 alters cell-wall composition and suppresses glucan-triggered immunity in plants
    Nat. Commun.2016, 7, 13188.


    A. Mertsch, S. Letschert, E. Memmel, M. Sauer, J. Seibel
    Synthesis and application of water soluble, photoswitchable cyanine dyes for bioorthogonal labeling of cell-surface carbohydrates
    Biosciences – Zeitschrift für Naturforschung C2016, 71, 347–354.


    J. Seibel
    ZNC opens a new chapter focussing on the emerging field of natural and natural-like compounds
    Biosciences – Zeitschrift für Naturforschung C 2016, 71, 93


    M. Ortiz-Soto, J. Seibel
    From gene to product: tailor-made oligosaccharides and polysaccharides by enzyme and substrate engineering
    Carbohydrate-Modifying Biocatalysts 2016, 535


    T. Walter, L. Collenburg, L. Japtok, B. Kleuser, S. Schneider-Schaulies, N. Müller, J. Becam, A. Schubert-Unkmeir, J. N. Konge, E. Bieberich and J. Seibel
    Incorporation and visualization of azido-functionalized N-oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells
    Chem. Commun. 2016, 52, 8612-8614


    M. Ortiz-Soto, J. Seibel
    Expression of Functional Human Sialyltransferases ST3Gal1 and ST6Gal1 in Escherichia coli
    PLoS One2016,  11, e0155410.


    L. Collenburg, T. Walter, A. Burgert, N. Müller, J. Seibel, L. Japtok, B. Kleuser, M. Sauer, S. Schneider-Schaulies
    A Functionalized Sphingolipid Analogue for Studying Redistribution during Activation in Living T Cells
    J. Immunol.2016, 196, 3951-3962.


    M. Kraus, J. Görl, M. Timm, J. Seibel
    Synthesis of the rare disaccharide nigerose by structure-based design of a phosphorylase mutant with altered regioselectivity
    Chem. Commun.2016, 52, 4625-4627.


    M. Gutmann, E. Memmel, A. Braun, J. Seibel, L. Meinel, T. Lühmann
    Biocompatible azide alkyne"click" reactions for surface decoration of glyco-engineered cells

    ChemBioChem2016, 17, 866-875. 

    M. Kraus, C. Grimm, J. Seibel
    Redesign of the active site of sucrose phosphorylase by a clash induced cascade of loop shifts

    ChemBioChem2016, 17, 33–36.

    C. Fleck, E. Memmel, M. Fölsing, B. Poll, T. Hackl, J. Seibel, W. Maison
    Synthesis and evaluation of neoglycoconjugates based on adamantyl scaffolds.
    Eur. J. Org. Chem.2015, 8, 1696–1710.

    E. Memmel, J. Seibel
    Metabolic Engineering of Bacteria.
    in Proceedings of the 3rd Beilstein Glyco-Bioinformatics Symposium 2013 (Herausgeber M. G. Hicks, C. Kettner, P. Seeberger)
    Beilstein Institut, Frankfurt/Main 2014, 1-9.

    D. Claes, E. Memmel, M. Holzapfel, J. Seibel, W. Maison
    High-Affinity Carbohydrate Binding by Trimeric Benzoboroxoles Measured on Carbohydrate Arrays.

    ChemBioChem2014, 15, 2450–2457.

    S. Letschert, A. Göhler, C. Franke, N. Bertleff-Zieschang, E. Memmel, S. Doose, J. Seibel, M. Sauer
    Super-Resolution Imaging of Plasma Membrane Glycans.
    Angew. Chem. Int. Ed.2014, 53(41), 10921–10924.

    U. T. Bornscheuer, K. Buchholz, J. Seibel
    Enzymatic degradation of (ligno-)celluloses.
    Angew. Chem. Int. Ed.2014, 53(41), 10876–10893.

    S. Bank, E. Heller, E. Memmel, J. Seibel, U. Holzgrabe, P. Kapková
    Matrix-assisted laser desorption/ionization tandem mass spectrometry of N-glycans derivatized with isonicotinic hydrazide and its biotinylated form.
    Rapid Commun. Mass Spectrom.2014, 28(15), 1745–1756.

    M. E. Ortiz-Soto, J. Seibel
    Biotechnological Synthesis and Transformation of Valuable Sugars in the Food and Pharmaceutical Industry.
    Current Organic Chemistry 2014, 18, 964–986.

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