A Huge Milestone: Our 4th Paper Published in Angewandte Chemie!
16.10.2024The 4th paper of the group, and of the year made it into Angewandte Chemie.
We’re thrilled to announce that our group’s fourth paper—in what has been an exciting and challenging year—has been published in Angewandte Chemie as a Full Research Article!
This paper combines extensive experimental and computational data to establish the first set of design rules for our aryliminopyrazole (AIP) photoswitches. Additionally, we demonstrate that our imines can isomerize in the condensed phase and, excitingly, report what appears to be the first-ever crystal structure of a metastable Z-imine (aldimine). This achievement would have seemed impossible without the breakthroughs from our first publication!
Congratulations to the entire team on this massive achievement!
Check out the paper (Open Access, though my OA budget is nearly gone!): Angewandte Chemie Link
Title: Switching Sides: Regiochemistry and Functionalization Dictate the Photoswitching Properties of Imines
Abstract:
Photoswitchable imines demonstrate light-dependent dynamic covalent chemistry and can function as molecular ratchets. However, the design of aryliminopyrazoles (AIPs) has been limited to N-pyrazole derivatives with ortho-pyrrolidine motifs. The impact of other functionalization patterns on the photoswitching properties remains unknown. Here, we present a systematic structure-property analysis and study how the photoswitching properties can be tuned through ortho- and para-functionalization of the phenyl ring in N-pyrazole and N-phenyl AIPs. This study establishes the first set of design rules for these AIP photoswitches and reports the most stable Z-isomer of an AIP to date, enabling its crystallization and resulting in the first reported crystal structure of a metastable Z-aldimine. Finally, we demonstrate that the AIPs are promising candidates for photoswitching in the condensed phase.