Prof. Dr. Reinhold Tacke


    1. R. Tacke, U. Wannagat, Syntheses and properties of bioactive organo-silicon compounds, Topics Curr. Chem. 84, 1-75 (1979).
    2. R. Tacke, Bioaktive Siliciumverbindungen, Chemie in unserer Zeit 14, 197-207 (1980).
    3. R. Tacke, Sila-Pharmaka: Kohlenstoff wird durch Silicium ersetzt, Umschau 82, 770 (1982).
    4. R. Tacke, Recent results in bioorganosilicon chemistry: novel sila-drugs and microbial transformations of organosilicon compounds, in: Organosilicon and Bioorganosilicon Chemistry: Structure, Bonding, Reactivity and Synthetic Application (Ed.: H. Sakurai), pp. 251-262, Ellis Horwood Ltd., Chichester 1985.
    5. R. Tacke, H. Zilch, Drug-design by sila-substitution and microbial transformations of organosilicon compounds: some recent results, L'Actualité Chimique 1986 (3), 75-82; reprint in: Silicon Compounds: Register and Review (Eds.: R. Anderson, B.C. Arkles, G.L. Larson), 4th ed., pp. 47-53, Petrarch Systems, Bristol PA 1987.
    6. R. Tacke, H. Zilch, Sila-substitution - a useful strategy for drug design ?,  Endeavour, New Series 10, 191-197 (1986).
    7. R. Tacke, B. Becker, Sila-substitution of drugs and biotransformation of organosilicon compounds, Main Group Met. Chem. 10, 169-197 (1987).
    8. G. Lambrecht, E. Mutschler, U. Moser, J. Riotte, M. Wagner, J. Wess, G. Gmelin, R. Tacke, H. Zilch, Heterogeneity in muscarinic receptors: evidence from pharmacological and electrophysiological studies with selective antagonists, in: International Symposium on Muscarinic Cholinergic Mechanisms (Eds.: S. Cohen, M. Sokolovsky), pp. 245-253, Freund Publishing House Ltd., London 1987.
    9. C. Syldatk, A. Stoffregen, A. Brans, K. Fritsche, H. Andree, F. Wagner, H. Hengelsberg, A. Tafel, F. Wuttke, H. Zilch, R. Tacke, Biotransformation as a new method for preparing optically active organometallic compounds, in: Enzyme Engineering 9, Ann. N.Y. Acad. Sci., Vol. 542 (Eds.: H.W. Blanch, A.M. Klibanov), pp. 330-338, The New York Academy of Sciences, New York 1988.
    10. R. Tacke, H. Linoh, Bioorganosilicon chemistry, in: The Chemistry of Organic Silicon Compounds, Part 2 (Eds.: S. Patai, Z. Rappoport), pp. 1143-1206, John Wiley & Sons Ltd., Chichester 1989.
    11. C. Syldatk, J. Fooladi, A. Stoffregen, M. Wettern, H. Hengelsberg, R. Tacke, Bioconversion of organosilicon compounds by immobilized algae, in: Proceedings of the Braunschweig Symposium on Applied Plant Molecular Biology (Eds.: G. Galling), pp. 474-479, Zentralstelle für Weiterbildung der TU Braunschweig, Braunschweig 1989.
    12. G. Lambrecht, J. Wess, R. Tacke, E. Mutschler, Heterogeneity of muscarinic receptors: evidence from structure-activity relationships of antimuscarinic agents related to pridinol and sila-pridinol, in: Trends in Medicinal Chemistry '88 (Eds.: H. van der Goot, G. Domány, L. Pallos, H. Timmerman), pp. 265-282, Elsevier Science Publishers B.V., Amsterdam 1989.
    13. G. Lambrecht, R. Feifel, U. Moser, M. Wagner-Röder, L.K. Choo, J. Camus, M. Tastenoy, M. Waelbroeck, C. Strohmann, R. Tacke, J.F. Rodrigues de Miranda, J. Christophe, E. Mutschler, Pharmacology of hexahydro-difenidol, hexahydro-sila-difenidol and related selective muscarinic antagonists, Trends Pharmacol. Sci. 10, Suppl. 60-64 (1989).
    14. M. Waelbroeck, M. Tastenoy, J. Camus, R. Feifel, E. Mutschler, C. Strohmann, R. Tacke, G. Lambrecht, J. Christophe, Stereoselectivity of the interaction of muscarinic antagonists with their receptors, Trends Pharmacol. Sci. 10, Suppl. 65-69 (1989).
    15. E. Mutschler, G. Lambrecht, U. Moser, R. Tacke, J. Wess, Subclassification of muscarinic receptors, in: Topics in Pharmaceutical Sciences 1989, Proceedings of the 49th International Congress of Pharmaceutical Sciences of F.I.P. (Eds.: D.D. Breimer, D.J.A. Crommelin, K.K. Midha), pp. 97-111, Fédération Internationale Pharmaceutique (F.I.P.), The Hague 1989.
    16. K. Fritsche, H. Hengelsberg, C. Syldatk, R. Tacke, F. Wagner, Enzymatic production of optically active organosilicon compounds, in: DECHEMA Biotechnology Conferences, Vol. 3, Part A (Eds.: D. Behrens, A.J. Driesel), pp. 149-152, VCH Verlagsgesellschaft, Weinheim 1989.
    17. C. Syldatk, J. Fooladi, A. Stoffregen, R. Tacke, F. Wagner, M. Wettern, Screening for matrices for viable cells, in: Physiology of Immobilized Cells (Eds.: J.A.M. de Bont, J. Visser, B. Mattiasson, J. Tramper), pp. 377-385, Elsevier Science Publishers B.V., Amsterdam 1990.
    18. R. Tacke, Silicium-Chemie im Spannungsfeld der Biowissenschaften, in: 40 Jahre Fonds der Chemischen Industrie 1950 - 1990 (Ed.: Verband der Chemischen Industrie e.V.
      - Fonds der Chemischen Industrie), pp. 51-62, Frankfurt 1990.
    19. R. Tacke, S. Brakmann, M. Kropfgans, C. Strohmann, F. Wuttke, G. Lambrecht, E. Mutschler, P. Proksch, H.-M. Schiebel, L. Witte, Bioorganosilicon chemistry - recent results, in: Frontiers of Organosilicon Chemistry (Eds.: A.R. Bassindale, P.P. Gaspar), pp. 218-228, The Royal Society of Chemistry, Cambridge 1991.
    20. R. Tacke, J. Becht, A. Lopez-Mras, J. Sperlich, Molecular λ5-silicates: synthesis, structure and properties of zwitterionic λ5-organospirosilicates and λ5-organofluorosilicates, J. Organomet. Chem. 446, 1-8 (1993).
    21. R. Tacke, J. Becht, O. Dannappel, M. Kropfgans, A. Lopez-Mras, M. Mühleisen, J. Sperlich, Zwitterionic λ5-organospirosilicates and λ5-organofluorosilicates: syntheses, structures, and properties, in: Progress in Organosilicon Chemistry (Eds.: B. Marciniec, J. Chojnowski), pp. 55-68, Gordon and Breach Publishers, Amsterdam 1995.
    22. D. Reichel, R. Tacke, P.G. Jones, G. Lambrecht, J. Gross, E. Mutschler, M. Waelbroeck, Biological recognition of enantiomeric silanes and germanes: syntheses and antimuscarinic properties of the enantiomers of the Si/Ge analogues cyclohexyl(hydroxymethyl)phenyl(2-piperidinoethyl)silane and -germane and their methiodides, in: Organosilicon Chemistry II ─ From Molecules to Materials (Eds.: N. Auner, J. Weis), pp. 231-236, VCH, Weinheim 1996.
    23. S.A. Wagner, S. Brakmann, R. Tacke, Biotransformation as a preparative method for the synthesis of optically active silanes, germanes, and digermanes: studies on the (R)-selective microbial reduction of MePh(Me3C)ElC(O)Me (El = Si, Ge), MePh(Me3Ge)GeC(O)Me, and MePh(Me3Si)GeC(O)Me using resting cells of Saccharomyces cerevisiae (DHW S-3) as biocatalyst, in: Organosilicon Chemistry II ─ From Molecules to Materials (Eds.: N. Auner, J. Weis), pp. 237-242, VCH, Weinheim 1996.
    24. R. Tacke, O. Dannappel, M. Mühleisen, Syntheses, structures, and properties of molecular λ5Si-silicates containing bidentate 1,2-diolato(2─) ligands derived from
      α-hydroxycarboxylic acids, acetohydroximic acid, and oxalic acid: new results in the chemistry of pentacoordinate silicon, in: Organosilicon Chemistry II
      ─ From Molecules to Materials (Eds.: N. Auner, J. Weis), pp. 427-446, VCH, Weinheim 1996.
    25. M. Mühleisen, R. Tacke, Syntheses and solution-state NMR studies of zwitterionic spirocyclic λ5Si-organosilicates containing two identical unsymmetrically substituted 1,2-benzenediolato(2–) ligands, in: Organosilicon Chemistry II ─ From Molecules to Materials (Eds.: N. Auner, J. Weis), pp. 447-451, VCH, Weinheim 1996.
    26. O. Dannappel, R. Tacke, Intramolecular ligand exchange of zwitterionic spirocyclic bis[1,2-benzenediolato(2–)]organosilicates: ab initio studies of the bis[1,2-benzenediolato(2–)]hydridosilicate(1–) ion, in: Organosilicon Chemistry II ─ From Molecules to Materials  (Eds.: N. Auner, J. Weis), pp. 453-458, VCH, Weinheim 1996.
    27. E. Mutschler, H.A. Ensinger, J. Gross, A. Leis, K. Mendla, U. Moser, O. Pfaff, D. Reichel, K. Rühlmann, R. Tacke, M. Waelbroeck, J. Wehrle, G. Lambrecht, Muscarinic receptor subtypes - search for selective agonists and antagonists, in: Perspectives in Receptor Research (Eds.: D. Giardinà, A. Piergentili, M. Migini), pp. 51-65, Elsevier Science Publishers B.V., Amsterdam 1996.
    28. R. Tacke, O. Dannappel, New zwitterionic silicon-oxygen compounds containing pentacoordinate silicon atoms: experimental and theoretical studies, in: Tailor-made Silicon-Oxygen Compounds ─ From Molecules to Materials (Eds.: R. Corriu, P. Jutzi), pp. 75-86, Vieweg, Braunschweig/Wiesbaden 1996.
    29. J. Heermann, R. Tacke, P.G. Jones, Germanium analogues of zwitterionic spirocyclic λ5Si-silicates, in: Organosilicon Chemistry III ─ From Molecules to Materials (Eds.: N. Auner, J. Weis), pp. 466-470, Wiley-VCH, Weinheim 1998.
    30. R. Tacke, S.A. Wagner, Chirality in bioorganosilicon chemistry, in: The Chemistry of Organic Silicon Compounds (Eds.: Z. Rappoport, Y. Apeloig), Vol. 2, Part 3, pp. 2363-2400, John Wiley & Sons Ltd., Chichester 1998.
    31. R. Tacke, T. Heinrich, T. Kornek, M. Merget, S.A. Wagner, J. Gross, C. Keim, G. Lambrecht, E. Mutschler, T. Beckers, M. Bernd, T. Reissmann, Bioorganogermanium chemistry: studies on C/Si/Ge bioisosterism, Phosphorus, Sulfur and Silicon 150/151, 69-87 (1999).
    32. R. Tacke, M. Pülm, B. Wagner, Zwitterionic pentacoordinate silicon compounds, Adv.
      Organomet. Chem. 44, 221-273 (1999).
    33. R. Tacke, Meilensteine in der Biochemie des Siliciums: von der Grundlagenforschung zu biotechnologischen Anwendungen, Angew. Chem. 111, 3197-3200 (1999); Milestones in the biochemistry of silicon: from basic research to biotechnological applications, Angew. Chem. Int. Ed. 38, 3015-3018 (1999).
    34. M. Merget, R. Tacke, Biocatalysis in preparative organosilicon chemistry: microbial reduction of rac-1-(4-fluorophenyl)-1-methyl-1-sila-2-cyclohexanone and microbial hydrolysis of rac-(SiS,CR/SiR,CS)-2-acetoxy-1-(4-fluorophenyl)-1-methyl-1-silacyclo-hexane, in Organosilicon Chemistry IV ─ From Molecules to Materials (Eds.: N. Auner, J. Weis), pp. 27-32, Wiley-VCH, Weinheim 2000.
    35. M. Merget, S. Bartoschek, R. Willeke, R. Tacke, Preparation of silicon- and germanium-containing α-amino acids, in Organosilicon Chemistry IV ─ From Molecules to Materials (Eds.: N. Auner, J. Weis), pp. 33-36, Wiley-VCH, Weinheim 2000.
    36. R. Willeke, R.E. Neugebauer, M. Pülm, O. Dannappel, R. Tacke, Syntheses, structures, and properties of zwitterionic monocyclic λ5Si-silicates, in Organosilicon Chemistry IV ─ From Molecules to Materials (Eds.: N. Auner, J. Weis), pp. 456-459, Wiley-VCH, Weinheim 2000.
    37. R.E. Neugebauer, R. Bertermann, R. Tacke, Isomerization of chiral zwitterionic monocyclic λ5Si-silicates, in Organosilicon Chemistry IV ─ From Molecules to Materials (Eds.: N. Auner, J. Weis), pp. 460-467, Wiley-VCH, Weinheim 2000.
    38. A. Biller, B. Pfrommer, M. Pülm, R. Tacke, Zwitterionic spirocyclic λ5Si-silicates containing diolato(2) ligands derived from acetohydroximic acid and benzohydroximic acid, in Organosilicon Chemistry IV ─ From Molecules to Materials (Eds.: N. Auner, J. Weis), pp. 468-472, Wiley-VCH, Weinheim 2000.
    39. B. Pfrommer, R. Tacke, Isoelectronic zwitterionic pentacoordinate silicon compounds with SiO4C and SiO5 frameworks, in Organosilicon Chemistry IV ─ From Molecules to Materials (Eds.: N. Auner, J. Weis), pp. 473-477, Wiley-VCH, Weinheim 2000.
    40. M. Pülm, R. Willeke, R. Tacke, The zwitterionic spirocyclic λ5Si-silicate [(dimethylammonio)methyl]bis[salicylato(2B)-O1,O3]silicate: experimental and computational studies, in Organosilicon Chemistry IV ─ From Molecules to Materials (Eds.: N. Auner, J. Weis), pp. 478-488, Wiley-VCH, Weinheim 2000.
    41. M. Bolboaca, A. Biller, C. Burschka, M. Penka, R. Tacke, W. Kiefer, Structural analysis of some anionic hexacoordinate silicon(IV) complexes by means of Raman and infrared spectroscopy, in Proceedings of the Eighteenth International Conference on Raman Spectroscopy (Eds.: J. Mink, G. Jalsovszky, G. Keresztury), pp. 599-600, John Wiley & Sons Ltd., Chichester 2002.
    42. R. Tacke, O. Seiler, Higher-coordinate silicon compounds with SiO5 and SiO6 skeletons, in Silicon Chemistry: From the Atom to Extended Systems (Eds.: P. Jutzi, U. Schubert), pp. 324-337, Wiley-VCH, Weinheim 2003.
    43. W. Bains, R. Tacke, Silicon chemistry as a novel source of chemical diversity in drug design, Curr. Opin. Drug Disc. Dev. 6, 526-543 (2003).
    44. O. Seiler, M. Fischer, M. Penka, R. Tacke, Synthesis and structural characterization of novel neutral hexacoordinate silicon(IV) complexes with SiO2N4 skeletons, in Organosilicon Chemistry VI – From Molecules to Materials, Vol. 1, (Eds.: N. Auner, J. Weis), pp. 303-308, Wiley-VCH, Weinheim 2005.
    45. J.O. Daiß, B. Müller, C. Burschka, W. Bains, J. Warneck, R. Tacke, s Ligands of the 1,4’-silaspiro[tetralin-1,4’-piperidine] type and the serotonin/noradrenaline reuptake inhibitor sila-venlafaxine: studies on C/Si bioisosterism, in Organosilicon Chemistry VI – From Molecules to Materials, Vol. 1, (Eds.: N. Auner, J. Weis), pp. 575-581, Wiley-VCH, Weinheim 2005.