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    First DFG Project for the Pöppler Group!


    At the end of February, we got the positiv news of our first DFG funded project on "Struktur-Eigenschaftsbeziehungen für mit Wirkstoffe beladene Polymermizellen aus detaillierten Strukturinformationen von Festkörper NMR Spektroskopie Untersuchungen kombiniert mit komplementären Techniken".

    In February, our project on structure-property relationships for polymeric micelles loaded with active substances got accepted by the DFG.

    Starting in April 2020 the DFG is supporting our studies on polymer-based drug delivery systems by solid-state NMR spectroscopy and complementary techniques with a research grant for the next three years.  Additionally, a PhD position is financed to also give the option of working more intensely on this project.

    This provides the basis for continuing the research, which was published in last year’s paper Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy. Through the first investigations some very interesting hypotheses have been made and it is now important to systematically test these in order to gain more detailed structural information and especially determine their effects on the behavior of the formulations. We will make use of proton detection at fast magic angle spinning as well as multinuclear solid-state NMR to characterize the samples in detail. In addition to this, polymers and optimized polymer-drug formulations will also be analyzed regarding their behaviour in biorelevant media. The overall aim of this project is to understand the relationship between structure and properties to find a guideline for designing suitable polymers as drug delivery systems on a rational basis, which is helping to improve the transport and absorption of drugs and finally benefits the patient.