SAMURI on the cover of Nat Chem Biol
06/02/2026The most recent Focus issue of Nature Chemical Biology features a collection of articles that showcase some of the recent progress in RNA chemical biology to reflect the synergy of mechanistic insights and technological innovations to drive RNA research forward.
The crystal structure of the SAM-analog utilizing ribozyme SAMURI reveals a fascinating active site architecture and provides new insights into the evolution of catalytic RNAs and riboswitches.
Chen, Okuda et al. structurally characterize the ribozyme SAMURI, which catalyzes the site-specific transfer of a methyl group from S-adenosylmethionine (SAM) to target RNA, thereby providing a foundation for the future development of RNA-labeling tools.
