Prof. Dr. Leane Lehmann

Contact

Phone:      +49 931 318 5481

Office hours

Lecture period:            Tuesdays 12 -1 pm

Non-lecuture period:   appointment per email

Curriculum Vitae

October 1991 – March 1996	Studium der Lebensmittelchemie, Universität Kaiserslautern.
13th March 1996	Erste Staatsprüfung in Lebensmittelchemie.
April 1996 - September 1996	Wissenschaftliche Abschlussarbeit und Einreichung der Diplomarbeit Experimentelle Arbeit: Abteilung für Kellerwirtschaft, Landes Lehr- und Forschungsanstalt für Landwirtschaft, Weinbau und Obstbau Neustadt a. d. Weinstraße. Diplomarbeit: Aromaprofile von 23 deutschen Silvanerweinen: Vergleich sensorischer und instrumenteller Daten. Institut für Lebensmittelchemie und Umwelttoxikologie, Universität Kaiserslautern.
25th May 1999	Diplom in Lebensmittelchemie. Note: “sehr gut”.
October 1996 - September 1997	Praktisches Jahr im Rahmen der Zweiten Staatsprüfung für Lebensmittelchemiker, Chemisches Lebensmitteluntersuchungsamt Speyer.
02nd December 1997	Zweite Staatsprüfung in Lebensmittelchemie.
Januar 1998 - Januar 2002	Doktorandin im Institut für Lebensmittelchemie und Toxikologie der Universität Karlsruhe.
01st Februar 2002	Dissertation (Prof. M. Metzler), Universität Karlsruhe. Titel: Untersuchungen zur Genotoxizität von estrogen-aktiven Stoffen Note: „summa cum laude“.
Februar 2002 - March 2009	Wissenschaftliche Angestellte im Institut für Angewandte Biowissenschaften, Abteilung für Lebensmittelchemie, Universität Karlsruhe.
2005	Forschungsprojekt “Mutagenicity of 4-monochlorobiphenyl in the liver of transgenic BigBlue rats” an der Universität von Iowa, College of Public Health, Department of Occupational and Environmental Health (Alexander Hollaender fellowship der Environmental Mutagen Society).
30th May 2008	Habilitation (Prof. M. Metzler) im Fach Lebensmittelchemie, Universität Karlsruhe. Titel der Habilitationsschrift: „Lebensmittelinhaltsstoffe als molekulare Modulatoren in der Kanzerogenese“.
Since April 2009	Inhaberin des Lehrstuhls für Lebensmittelchemie im Institut für Pharmazie und Lebensmittelchemie der Universität Würzburg.

Activities in bodies and memberships

Bodies/Offices
since 2019	Member of the Gemeinsamen Expertenkommission Kommission zur Einstufung von Borderline-Stoffen, die als Lebensmittel oder Lebensmittelzutat in den Verkehr gebracht werden des Bundesamts für Verbraucherschutz und Lebensmittelsicherheit (BVL) und des Bundesinstituts für Arzneimittel und Medizinprodukte (BfArM)
Memberships
Member of  Gesellschaft für Mykotoxinforschung e.V.
Member of Gesellschaft für Umwelt - Mutationsforschung e.V. (GUM)
Member of Gesellschaft Deutscher Chemiker (GDCh)
Member of  Society of Toxicology (SOT)
Member of American Association for Cancer Research (AACR)
Member of Deutsche Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie e.V. (DGPT)

 

Publications

Reviewed scientific journal articles

Kleider C, Calderón G J, Pemp D, Esch HL, Lehmann L (2022). Validation of a GC- and LC-MS/MS based method for the quantification of 22 estrogens and its application to human plasma. Steroids. doi.org/10.1016/j.steroids.2022.109077. Epub 2022 July 02.

Wunder J, Pemp D, Cecil A, Mahdiani M, Hauptstein R, Schmalbach K, Geppert LN, Ickstadt K, Esch HL, Dandekar T, Lehmann L (2022). Influence of breast cancer risk factors on proliferation and DNA damage in human breast glandular tissues: role of intracellular estrogen levels, oxidative stress and estrogen biotransformation. Arch Toxicol. doi.org/10.1007/s00204-021-03198-7. Epub 2021 December 18.

Esch HL and Lehmann L (2021) Isoflavones: Toxicological aspects and efficacy. In: Nutraceuticals. DOI 10.1016/b978-0-12-821038-3.00045-8

Pemp D, Geppert LN, Wigmann C, Kleider C, Hauptstein R, Schmalbach K, Ickstadt K, Esch HL, Lehmann L (2020). Influence of breast cancer risk factors and intramammary biotransformation on estrogen homeostasis in the human breast. Arch Toxicol. doi.org/10.1007/s00204-020-02807-1. Epub 2020 June 22.

ter Mors B, Pemp D, Lehmann L, Lorson T, Meinel L (2020). Comparison of polysorbate 20 qualities. Pharm. Ind. 82, Nr. 8, 1064-1071.

Pemp D, Kleider C, Schmalbach K, Hauptstein R, Geppert LN, Köllmann C, Ickstadt K, Eckert P, Neshkova I, Jakubietz R, Esch HL, Lehmann L (2019). Qualitative and quantitative differences in estrogen biotransformation in human breast glandular and adipose tissues: implications for studies using mammary biospecimens. Arch Toxicol. doi.org/10.1007/s00204-019-02564-w. Epub 2019 September 05.

Hoffmann M, Mufusama Koy Sita J-P, Kleider C, Gunesch S, Rothmund B, Lehmann L, Bringmann G, Decker M. (2019). (R)‐Tonkafuranone and related compounds: Improved synthesis, stereochemical purity in nature, and bioactivities of the pure enantiomers. Flavour and Fragrance Journal, Volume 34 (5), 329-338. DOI 10.1002/ffj.3513. Epub 2019 June 21.

Pemp D, Esch HL, Hauptstein R, Möller FJ, Zierau O, Bosland MC, Geppert LN, Kleider C, Schlereth K, Vollmer G, Lehmann L (2019). Novel insight in estrogen homeostasis and bioactivity in the ACI rat model of estrogen-induced mammary gland carcinogenesis. Arch Toxicol. Volume 93 (7), 1979-92. doi: 10.1007/s00204-019-02483-w. Epub 2019 May 25.

Christa M, Weng AM, Geier B, Wörmann C, Scheffler A, Lehmann L, Oberberger J, Kraus BJ, Hahner S, Störk S, Klink T, Bauer WR, Hammer F, Köstler H. (2019). Increased myocardial sodium signal intensity in Conn's syndrome detected by 23Na magnetic resonance imaging. Eur Heart J Cardiovasc Imaging 20(3):263-270. doi: 10.1093/ehjci/jey134.

Hüser S, Guth S, Joost HG, Soukup ST, Köhrle J, Kreienbrock L, Diel P, Lachenmeier DW, Eisenbrand G, Vollmer G, Nöthlings U, Marko D, Mally A, Grune T, Lehmann L, Steinberg P, Kulling SE (2018). Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation. Arch. Toxicol. 92(9), pp. 2703-2748. doi: 10.1007/s00204-018-2279-8. Epub 2018 Aug 21.

Lehmann L, Soukup ST, Gerhauser C, Vollmer G, Kulling SE (2017) [Isoflavone-containing dietary supplements]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz doi:10.1007/s00103-016-2497-2

Helle J, Keiler AM, Zierau O, Dörfelt P, Vollmer G, Lehmann L, Chittur SV, Tenniswood M, Welsh J, Kretzschmar G (2017). Effects of the aryl hydrocarbon receptor agonist 3-methylcholanthrene on the 17β-estradiol regulated mRNA transcriptome of the rat uterus. J Steroid Biochem Mol Biol 171:133-143. doi: 10.1016/j.jsbmb.2017.03.004. Epub 2017 Mar 8.

Esch HL, Kleider C, Scheffler A, Lehmann L (2016). Isoflavones: Toxicological aspects and efficacy. In: Nutraceuticals: Efficacy, Safety and Toxicity edited by R.C. Gupta. Elsevier, pp. 467-489.

Hiltensperger G, Hecht N, Kaiser M, Rybak JC, Hoerst A, Dannenbauer N, Müller-Buschbaum K, Bruhn H, Esch H, Lehmann L, Meinel L, Holzgrabe U (2016).Quinolone Amides as Antitrypanosomal Lead Compounds with In Vivo Activity. Antimicrob Agents Chemother. Jul 22;60(8):4442-52. doi: 10.1128/AAC.01757-15. Print 2016 Aug.

Möller F, Pemp D, Soukup S, Wende K, Zhang X, Zierau O, Muders M, Bosland M, Kulling S, Lehmann L,  Vollmer G (2016). Soy isoflavone exposure through all life stages accelerates 17β-estradiol-induced mammary tumor onset and growth, yet reduces tumor burden, in ACI rats. Arch. Toxicol. pp. 1907-1916. doi:10.1007/s00204-016-1674-2

Scheffler A, Albrecht A, Esch H, Lehmann L. Data in support of the mutagenic potential of the isoflavone irilone in cultured V79 cells Toxicol. Lett. 234 (2015), pp. 474-487. DOI:10.1016/j.dib.2015.07.010

Scheffler A, Albrecht A, Esch H, Lehmann L. Mutagenic potential of the isoflavone irilone in cultured V79 cells. Toxicol. Lett. 234 (2015), pp. 81-91. 10.1016/j.toxlet.2015.02.013

Cecil A, Ohlsen K, Menzel T, François P, Schrenzel J, Fischer A, Dörries K, Selle M, Lalk M, Hantzschmann J, Dittrich M, Liang C, Bernhardt J, Ölschläger TA, Bringmann G, Bruhn H, Unger M, Ponte-Sucre A, Lehmann L, Dandekar T. Modelling antibiotic and cytotoxic isoquinoline effects in Staphylococcus aureus, Staphylococcus epidermidis and mammalian cells. Int J Med Microbiol. 2015 Jan;305(1):96-109. doi: 10.1016/j.ijmm.2014.11.006. Epub 2014 Nov 27

Pfenning C, Esch HL, Fliege R, Lehmann L. (2016, Epub 2014). The mycotoxin patulin reacts with DNA bases with and without previous conjugation to GSH: implication for related α,β-unsaturated carbonyl compounds? Arch. Toxicol., Volume 90 (2), 433-448. DOI 10.1007/s00204-014-1443-z.

Blei T, Soukup ST, Schmalbach K, Pudenz M, Möller FJ, Egert B, Wörtz N, Kurrat A, Müller D, Vollmer G, Gerhäuser C, Lehmann L, Kulling SE, Diel P. Dose-dependent effects of isoflavone exposure during early lifetime on the rat mammary gland: Studies on estrogen sensitivity, isoflavone metabolism and DNA methylation.Mol Nutr Food Res. 2014 Nov 20. 59(2):270-83 doi: 10.1002/mnfr.201400480.

Kulling SE, and Lehmann L (2014) Isoflavone und ihre Wirkung: Datenlage und aktuelle Forschungsprojekte [dt].  Lebensmittelchemie 68, 1-16.

Lutter S, Schmalbach K, Esch HL, Lehmann L. The isoflavone irilone contributes to the estrogenic potential of dietary supplements containing red clover. (2013) Arch Toxicol. 88(2), 309-21, DOI: 10.1007/s00204-013-1114-5. Print 2014 Feb.

Lödige M, Lewis MD, Paulsen ES, Esch HL, Pradel G, Lehmann L, Brun R, Bringmann G, Mueller AK. A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages. Int J Med Microbiol. 2013 Aug 5. doi:pii: S1438-4221(13)00101-X.10.1016/j.ijmm.2013.07.005.

Menzel TM, Tischer M, François P, Nickel J, Schrenzel J, Bruhn H, Albrecht A, Lehmann L, Holzgrabe U, Ohlsen K. Mode-of-action studies of the novel bisquaternary bisnaphthalimide MT02 against Staphylococcus aureus. Antimicrob Agents Chemother. 2011 Jan;55(1):311-20. doi: 10.1128/AAC.00586-10. 

Jacobus JA, Wang B, Maddox C, Esch H, Lehmann L, Robertson LW, Wang K, Kirby P, Ludewig G (2010). 3-Methylcholanthrene (3-MC) and 4-Chlorobiphenyl (PCB3) genotoxicity is gender-related in Fischer 344 transgenic rats. Environ. Int. 36, 970-979.

Ludewig G, Lehmann L, Esch H, Robertson LW (2008). Metabolic Activation of PCBs to Carcinogens in Vivo - A Review. Environ. Toxicol. Pharmacol. 25, 241-246. doi10.1016/j.etap.2007.10.029.

Lehmann L, Wagner J (2008). Gene expression of 17beta-estradiol-metabilozing isozymes: comparison of normal human mammary gland to normal human liver and to cultured human breast adenocarcionoma cells. Adv. Exp. Med. Biol. 617, 617-624. 

Wagner J, Jiang L, Lehmann L (2008). Phytoestrogens modulate the expresssion of 17beta-estradiol metabolizing enzymes in cultured MCF-7 cells. Adv. Exp. Med. Biol. 617, 625-632.

Lehmann L, Jiang L, Wagner J (2008). Soy isoflavones reduce the expression of catechol-O-methyltransferase in cultured MCF-7 cells. Carcinogenesis 29, 363-370.

Zettner MA, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L (2007). Quinoid metabolites of 4-monochlorobiphenyl (PCB3) induce gene mutations in cultured Chinese hamster V79 cells. Toxicol. Sci. 100, 88-98. doi: 10.1093/toxsci/kfm204.

Rohnstock A, Lehmann L (2007). Evaluation of the probe dihydrocalcein acetoxymethylester as an indicator of reactive oxygen species formation and comparison with oxidative DNA base modification determined by modified alkaline elution technique. Toxicol. In Vitro 21, 1552-1562.

Newill H, Loske R, Johannes C, Lorenz RL, Lehmann L (2007). Oxidation products of stigmasterol interfere with the action of the female sex hormone 17β-estradiol in cultured human breast and endometrium cell lines. Mol. Nutr. Food Res. 51, 888-898.

Lehmann L, Esch HL, Kirby P, Robertson LW, Ludewig G (2007). 4-Monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fischer 344 rats. Carcinogenesis 28, 471-478.

Schumacher DM, Müller C, Metzler M, Lehmann L (2006). DNA-DNA cross-links contribute to the mutagenic potential of the mycotoxin patulin. Toxicol. Lett. 166, 268-275.

Brugger E-M, Wagner J, Schumacher DM, Podlech J, Metzler M, Lehmann L (2006). Mutagenicity of the mycotoxin alternariol in cultured mammalian cells. Toxicol. Lett. 164, 221-230.

Lehmann L, Wagner J, Metzler M (2006). Estrogenic and clastogenic potential of the mycotoxin alternariol in cultured mammalian cells. Food Chem. Toxicol. 44, 398-408.

Wagner J, Lehmann L (2006). Estrogens modulate the gene expression of Wnt-7a in cultured endometrial adenocarcinoma cells. Mol. Nutr. Food Res. 50, 368-372.

Schumacher DM, Wagner J, Metzler M, Lehmann L (2005). Influence of decreased intracellular glutathione level on the mutagenicity of patulin in cultured mouse lymphoma cells. Mycotoxin Res. 21, 150-152.

Schumacher DM, Metzler M, Lehmann L (2005). Mutagenicity of the mycotoxin patulin in cultured V79 Chinese hamster cells and its modulation by intracellular glutathione. Arch. Toxicol. 79, 110-121.

Lehmann L, Esch HL, Wagner J, Rohnstock L, Metzler M (2005). Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of daidzein in cultured human Ishikawa cells. Toxicol. Lett. 158, 72-86.

Lehmann L, Metzler M (2004). Bisphenol A and its methylated congeners inhibit growth and interfere with microtubules in human fibroblasts in vitro. Chem. Biol. Interact. 147, 273-285.

Lehmann L, Metzler M (2004). Genotoxic potential of the phytoestrogen resveratrol in cultured V79 Chinese hamster fibroblasts. In: Senate Commission on Food Safety SKLM (Hrsg.): Functional Foods: Safety Aspects. Deutsche Forschungsgemeinschaft, Wiley-VCH Verlag Weinheim, pp. 315-318.

Metzler M, Pfeiffer E, Lehmann L (2004). Influence of phytoestrogens on the biotransformation of endogenous estrogens. In: Senate Commission on Food Safety SKLM, (Hrsg.): Functional Foods: Safety Aspects. Deutsche Forschungsgemeinschaft, Wiley-VCH Verlag Weinheim, pp. 238-246.

Schmitt E, Lehmann L, Metzler M, Stopper H (2002). Hormonal and genotoxic activity of resveratrol. Toxicol. Lett. 136, 133-142.

Kulling SE, Lehmann L, Metzler M (2002). Oxidative metabolism and genotoxic potential of major isoflavone phytoestrogens. J. Chromat. B, 777, 211- 218.

Kulling SE, Lehmann L, Mayer S, Metzler M (2000). Genotoxic potential of isoflavone and coumestane phytoestrogens. In: Eisenbrand G, Dayan AD, Elias PS, Grunow W, Schlatter J (Hrsg.): Carcinogenic and Anticarcinogenic Factors in Food. Deutsche Forschungsgemeinschaft, Wiley-VCH Verlag Weinheim, pp. 489-492.