Deutsch Intern
Institute for sustainable chemistry & catalysis with boron - ICB

Sila-Trifluperidol, a Silicon Analogue of the Dopamine (D2) Receptor Antagonist Trifluperidol

03/19/2010
Trifluorperidol
Trifluorperidol

Trifluperidol (2a) is a dopamine (D2) receptor antagonist of the butyrophenone type. Carbon/silicon exchange (sila-substitution) in the 4-position of the piperidine ring of 2a (R3COH → R3SiOH) results in sila-trifluperidol (2b). The silanol 2b was synthesized in a multistep synthesis, starting from triethoxy(vinyl)silane, and was isolated as the hydrochloride 2b·HCl. Compound 2b·HCl was structurally characterized by single-crystal X-ray diffraction and solution NMR spectroscopy, and the stability of the silanol 2b in aqueous solutions at different pH values was studied by ESI-MS experiments. In addition, the pharmacological profiles of the C/Si analogues trifluperidol (2a) and sila-trifluperidol (2b) and of the related compounds haloperidol (1a) and sila-haloperidol (1b) were studied in functional receptor assays at human dopamine D1 and D2 receptors. Sila-substitution of 1a (→ 1b) and 2a (→ 2b) affects the pharmacological properties significantly.

Published by: Reinhold Tacke*†, Binh Nguyen†, Christian Burschka†, W. Peter Lippert†, Alexandra Hamacher‡, Christian Urban‡ and Matthias U. Kassack‡

Organometallics, Article ASAP

DOI10.1021/om901011t

Publication Date (Web): March 5, 2010

Back